{"id":"W2302583067","doi":"10.1126/science.aad9195","title":"HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen","year":2016,"lang":"en","type":"article","venue":"Science","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":483,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"SLAC National Accelerator Laboratory; Biological and Environmental Research; National Institute of Allergy and Infectious Diseases; National Center for Research Resources; National Institute of General Medical Sciences; International AIDS Vaccine Initiative; National Institutes of Health; Office of Science; Howard Hughes Medical Institute; Helen Hay Whitney Foundation; U.S. Department of Energy","keywords":"Immunogen; Germline; Virology; HIV vaccine; Antibody; Biology; Human immunodeficiency virus (HIV); Immunology; Monoclonal antibody; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001698356,0.0002450693,0.0001056302,0.0001932373,0.00007730819,0.0002059546,0.0001657902,0.0002246067,0.001198884],"category_scores_gemma":[0.0001585778,0.0001669647,0.0000952086,0.00008287927,0.0001620617,0.0001355071,0.0002314027,0.0004887899,0.0003043651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001465774,"about_ca_system_score_gemma":0.0001061702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001695337,"about_ca_topic_score_gemma":0.0003236141,"domain_scores_codex":[0.9998991,0.00002346482,0.000004843389,0.00002587336,0.00002129255,0.00002523275],"domain_scores_gemma":[0.9999193,0.00002506458,0.00002000117,0.00001322288,0.000009671803,0.00001268744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003427361,0.00001480497,0.0003131868,0.000009361121,0.000001687803,0.00001958448,0.000008262429,0.0001200819,0.9976222,0.0001385349,0.00002756319,0.001690479],"study_design_scores_gemma":[0.00001366321,0.0002703025,0.003199364,0.000005533952,0.000008333521,0.0004195876,0.00001793541,0.002316051,0.9920385,0.0001742021,0.001533315,0.000003183781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900811,0.0003454882,0.007420655,0.00005606717,0.000008631896,0.00003312831,0.0001169724,0.00008731319,0.001850532],"genre_scores_gemma":[0.9874493,0.0002804142,0.01058406,0.00009683279,0.000004676019,0.00002929731,0.0002065099,0.00002513989,0.001323755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001198884,"threshold_uncertainty_score":0.004010677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009817944776738183,"score_gpt":0.2825021617069066,"score_spread":0.2726842169301684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}