{"id":"W2302583067","doi":"10.1126/science.aad9195","title":"HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen","year":2016,"lang":"en","type":"article","venue":"Science","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":483,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"SLAC National Accelerator Laboratory; Biological and Environmental Research; National Institute of Allergy and Infectious Diseases; National Center for Research Resources; National Institute of General Medical Sciences; International AIDS Vaccine Initiative; National Institutes of Health; Office of Science; Howard Hughes Medical Institute; Helen Hay Whitney Foundation; U.S. Department of Energy","keywords":"Immunogen; Germline; Virology; HIV vaccine; Antibody; Biology; Human immunodeficiency virus (HIV); Immunology; Monoclonal antibody; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006769155,0.0001460694,0.0001671523,0.0001032587,0.0004798252,0.00004075608,0.0005744436,0.00007638566,0.0005916354],"category_scores_gemma":[0.0001426935,0.00008993318,0.00006035617,0.0003125916,0.0008955326,0.0002890742,0.000158132,0.0001240845,0.007437587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008788319,"about_ca_system_score_gemma":0.0001781214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004093747,"about_ca_topic_score_gemma":0.000001744179,"domain_scores_codex":[0.9982599,0.0001147605,0.0002162964,0.0004741595,0.00009974789,0.0008351296],"domain_scores_gemma":[0.9992957,0.0001266928,0.00007826617,0.0003296698,0.00009671749,0.00007296322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003311784,0.00006419087,0.006549474,0.000004537902,0.0000202006,0.000006295988,0.000120216,2.31832e-7,0.9775219,0.00003816539,0.01068334,0.004958327],"study_design_scores_gemma":[0.0009763124,0.0001359095,0.005993555,0.00004813062,0.000007842645,0.00001577376,0.00004269549,9.706952e-7,0.9040352,0.00003643187,0.0885521,0.0001551115],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991402,0.004376091,0.0003366799,0.0008527903,0.0004801573,0.0002964274,0.0002303519,0.00008764815,0.001937872],"genre_scores_gemma":[0.9846478,0.0002894624,0.0002624222,0.0000550405,0.00002228656,0.00001676801,0.00005566214,0.00001023261,0.01464031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07786876,"threshold_uncertainty_score":0.9933352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009817944776738183,"score_gpt":0.2825021617069066,"score_spread":0.2726842169301684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}