{"id":"W2303909027","doi":"10.1073/pnas.1601089113","title":"Suramin inhibits cullin-RING E3 ubiquitin ligases","year":2016,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"Cullin; Suramin; Ubiquitin ligase; Ubiquitin; Druggability; Ubiquitin-Protein Ligases; Cell biology; Biology; Proteasome; Enzyme; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009837922,0.0002629478,0.0002527878,0.0001401908,0.000116836,0.0002726605,0.0002113629,0.0002347962,0.0009041335],"category_scores_gemma":[0.0001064776,0.0001002546,0.0001493887,0.00008582639,0.0001199096,0.0001358147,0.0001346165,0.0003293002,0.0002672473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003339947,"about_ca_system_score_gemma":0.0001583516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001174233,"about_ca_topic_score_gemma":0.002160314,"domain_scores_codex":[0.9998906,0.00001862591,0.00001344584,0.00001486856,0.00003789701,0.0000244986],"domain_scores_gemma":[0.9999412,0.0000170791,0.00001115493,0.000006231206,0.000009343529,0.00001496383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003965088,0.0001018704,0.0003310292,0.00006660107,0.00002098351,0.00009633086,0.00001552466,0.0003251201,0.9915189,0.0001697087,0.0001447439,0.006812516],"study_design_scores_gemma":[0.00004897284,0.0007764922,0.002545033,0.000003603282,0.00002029302,0.0001853628,0.00001691127,0.001181011,0.9918218,0.00003759536,0.00335826,0.000004540035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913338,0.003422749,0.001267862,0.0001138758,0.00003737393,0.00003021866,0.0002658767,0.00006655524,0.003461692],"genre_scores_gemma":[0.9955369,0.001610877,0.0004549383,0.00003960749,0.000006424343,0.00001084512,0.0002248986,0.000005021295,0.002110575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001174233,"threshold_uncertainty_score":0.003024638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03801978314991811,"score_gpt":0.2913651264205876,"score_spread":0.2533453432706695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}