{"id":"W2304028829","doi":"10.1016/j.jaad.2016.02.1164","title":"Apremilast, an oral phosphodiesterase-4 inhibitor, in the treatment of palmoplantar psoriasis: Results of a pooled analysis from phase II PSOR-005 and phase III Efficacy and Safety Trial Evaluating the Effects of Apremilast in Psoriasis (ESTEEM) clinical trials in patients with moderate to severe psoriasis","year":2016,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; Innovaderm (Canada)","funders":"Celgene","keywords":"Apremilast; Medicine; Psoriasis; Dermatology; Phase (matter); Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01630523,0.001715224,0.005402151,0.001415125,0.0003329942,0.001755657,0.0005546549,0.0008508851,0.00230093],"category_scores_gemma":[0.007695512,0.0007781023,0.008768418,0.001068367,0.0004652282,0.0008889862,0.0006488127,0.001283759,0.0002972129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006337916,"about_ca_system_score_gemma":0.0008994245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005677728,"about_ca_topic_score_gemma":0.001577524,"domain_scores_codex":[0.9927986,0.004994837,0.0006722169,0.000652929,0.0006763866,0.0002050232],"domain_scores_gemma":[0.9955233,0.001887764,0.001570185,0.0003487359,0.0003238131,0.0003461576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.6838072,0.001851865,0.02200777,0.008040805,0.186444,0.0001852844,0.0001409957,0.001683233,0.0113747,0.00008761704,0.001935967,0.08244051],"study_design_scores_gemma":[0.3917047,0.1020977,0.1537503,0.0008433777,0.337857,0.0008651692,0.00018578,0.00251385,0.005722686,0.0003796294,0.003913936,0.000165831],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8557025,0.133196,0.003213157,0.0008764046,0.0004128379,0.001598989,0.002651042,0.0002345938,0.002114518],"genre_scores_gemma":[0.9815009,0.01331945,0.001661198,0.0004901512,0.0004116391,0.0004717497,0.001398498,0.00003500489,0.0007115407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01630523,"threshold_uncertainty_score":0.08623129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.042796572009189,"score_gpt":0.3684748574190304,"score_spread":0.3256782854098414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}