{"id":"W2304231620","doi":"10.1093/abbs/gmw013","title":"Macrophage-activating lipopeptide-2 downregulates the expression of ATP-binding cassette transporter A1 by activating the TLR2/NF-кB/ZNF202 pathway in THP-1 macrophages","year":2016,"lang":"en","type":"article","venue":"Acta Biochimica et Biophysica Sinica","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta","funders":"National Natural Science Foundation of China","keywords":"ABCA1; TLR2; Efflux; Lipopeptide; Chemistry; THP1 cell line; Cell biology; NF-κB; ABCG1; Signal transduction; Transporter; Biochemistry; Biology; TLR4; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002097713,0.0004481827,0.0005337297,0.0002293503,0.0001761868,0.0002976887,0.0001800546,0.0003273757,0.001213235],"category_scores_gemma":[0.00009875312,0.0001981585,0.0004059877,0.000221684,0.0003132298,0.0002688325,0.0001851796,0.0008518038,0.0004344551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001981005,"about_ca_system_score_gemma":0.0002269165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004049769,"about_ca_topic_score_gemma":0.0006009375,"domain_scores_codex":[0.99975,0.00004428754,0.00003525917,0.00004000504,0.00006293585,0.00006757965],"domain_scores_gemma":[0.9999095,0.00001232351,0.00002846045,0.00001109805,0.00001461696,0.00002388767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004023122,0.00008392898,0.0001522947,0.0001276293,0.00001146537,0.00009739563,0.00002334623,0.00004565386,0.9980931,0.00004550415,0.00008718548,0.0008302803],"study_design_scores_gemma":[0.0001248534,0.0007860422,0.005069699,0.00001317299,0.00005312028,0.0003262183,0.00008905378,0.001062075,0.9891956,0.00006199136,0.003207101,0.00001122143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891186,0.004289394,0.003342861,0.0003843184,0.0002115336,0.0000710341,0.001012627,0.0001241061,0.001445616],"genre_scores_gemma":[0.9878508,0.002702159,0.003944052,0.0003291485,0.00008146989,0.0001750609,0.001031627,0.00002527563,0.003860391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001213235,"threshold_uncertainty_score":0.004058659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01258677856521657,"score_gpt":0.2568167106064004,"score_spread":0.2442299320411839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}