{"id":"W2304231620","doi":"10.1093/abbs/gmw013","title":"Macrophage-activating lipopeptide-2 downregulates the expression of ATP-binding cassette transporter A1 by activating the TLR2/NF-кB/ZNF202 pathway in THP-1 macrophages","year":2016,"lang":"en","type":"article","venue":"Acta Biochimica et Biophysica Sinica","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta","funders":"National Natural Science Foundation of China","keywords":"ABCA1; TLR2; Efflux; Lipopeptide; Chemistry; THP1 cell line; Cell biology; NF-κB; ABCG1; Signal transduction; Transporter; Biochemistry; Biology; TLR4; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007280422,0.0005517351,0.0008340034,0.0001344966,0.0002824467,0.00007504238,0.0006579516,0.000244895,0.0001040448],"category_scores_gemma":[0.0002663507,0.0002583643,0.0003888348,0.0005903837,0.0005058864,0.0003924883,0.0002256128,0.0007384085,0.0000225571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006740877,"about_ca_system_score_gemma":0.0001302904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001266019,"about_ca_topic_score_gemma":0.0000112563,"domain_scores_codex":[0.9965654,0.000295086,0.001042473,0.0007789609,0.0006056199,0.0007124838],"domain_scores_gemma":[0.9966009,0.001217115,0.0007218525,0.001192552,0.0001003256,0.0001672322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003314916,0.0003260674,0.0003465012,0.00007006606,0.00008276677,0.00001090998,0.002150447,8.557831e-7,0.9748807,0.00004011387,0.001079379,0.02068069],"study_design_scores_gemma":[0.002012133,0.0001748588,0.03528797,0.001060607,0.00006077288,0.00002046735,0.0003995623,0.0000119446,0.9472358,0.00005041111,0.013351,0.000334443],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776139,0.0002811517,0.00002210231,0.02035475,0.0002236759,0.00074169,0.0001916,0.00008670615,0.0004844738],"genre_scores_gemma":[0.9965285,0.0002873734,0.0003393112,0.001407324,0.0004490172,0.00006909033,0.00005085278,0.0001023883,0.0007661266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03494146,"threshold_uncertainty_score":0.9999869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01258677856521657,"score_gpt":0.2568167106064004,"score_spread":0.2442299320411839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}