{"id":"W2304370660","doi":"10.1089/nat.2015.0593","title":"Considerations for the Characterization and Interpretation of Results Related to Alternative Complement Activation in Monkeys Associated with Oligonucleotide-Based Therapeutics","year":2016,"lang":"en","type":"review","venue":"Nucleic Acid Therapeutics","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Oligonucleotide; Computational biology; Complement (music); Complement system; Alternative complement pathway; Mechanism (biology); Biology; Pharmacology; Medicine; Immunology; Biochemistry; Phenotype; DNA; Gene; Epistemology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005477412,0.0007883204,0.001605656,0.003725861,0.0005179563,0.002046685,0.001218839,0.002383982,0.001974028],"category_scores_gemma":[0.004760438,0.0003084657,0.0007787169,0.002002426,0.002172361,0.002949467,0.001055082,0.003082301,0.001271881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009334841,"about_ca_system_score_gemma":0.002073686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007861448,"about_ca_topic_score_gemma":0.001269251,"domain_scores_codex":[0.9978867,0.0007464262,0.0002761909,0.0002269333,0.000787584,0.00007605732],"domain_scores_gemma":[0.9956013,0.003055826,0.0003295656,0.0001625095,0.0007751224,0.00007563682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001254431,0.0001346837,0.000746419,0.02379873,0.000122566,0.001448114,0.0006094268,0.0004830689,0.02295391,0.03511295,0.01499158,0.8994732],"study_design_scores_gemma":[0.0000168889,0.0002554226,0.001400013,0.007195771,0.0001864089,0.007992145,0.0004733396,0.0001922314,0.01191692,0.01660964,0.9537023,0.00005901183],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004359535,0.9914336,0.002484869,0.001628865,0.0004475673,0.00002782919,0.00003487595,0.00001574992,0.003490814],"genre_scores_gemma":[0.003574523,0.9890455,0.004104498,0.001094685,0.0006757174,0.00006237813,0.00006255404,0.000007695435,0.001372424],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005477412,"threshold_uncertainty_score":0.02896768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08239835438761318,"score_gpt":0.3681652381382253,"score_spread":0.2857668837506121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}