{"id":"W2304370660","doi":"10.1089/nat.2015.0593","title":"Considerations for the Characterization and Interpretation of Results Related to Alternative Complement Activation in Monkeys Associated with Oligonucleotide-Based Therapeutics","year":2016,"lang":"en","type":"review","venue":"Nucleic Acid Therapeutics","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Oligonucleotide; Computational biology; Complement (music); Complement system; Alternative complement pathway; Mechanism (biology); Biology; Pharmacology; Medicine; Immunology; Biochemistry; Phenotype; DNA; Gene; Epistemology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006602605,0.0003858353,0.001021978,0.0004043924,0.0001340487,0.00004941073,0.0001736691,0.0002788633,0.00001927582],"category_scores_gemma":[0.0003359543,0.0002290248,0.0001405219,0.0005039719,0.0001869121,0.0001023982,0.00005134727,0.0004215537,0.000004878731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006518739,"about_ca_system_score_gemma":0.0006128623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001191173,"about_ca_topic_score_gemma":0.0000222159,"domain_scores_codex":[0.9974663,0.0003543428,0.001019509,0.000433756,0.0004102968,0.000315838],"domain_scores_gemma":[0.9955394,0.002541786,0.0008226092,0.0004651373,0.0005581534,0.00007294182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001023527,0.0001963039,0.00003257495,0.0008370508,0.001895688,0.000002894779,0.001985236,0.00002772439,0.002329971,0.0007402053,0.00002281776,0.990906],"study_design_scores_gemma":[0.04308099,0.009180482,0.005372962,0.1131482,0.01340718,0.00007176142,0.001038041,0.1280533,0.01310448,0.00239968,0.6681187,0.00302429],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02778645,0.6825738,0.1782126,0.03677496,0.0009235826,0.06628491,0.005997232,0.0005510639,0.0008953838],"genre_scores_gemma":[0.2253178,0.7689072,0.001485909,0.001839734,0.00007522156,0.0006529223,0.001372157,0.0002166783,0.000132339],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9878817,"threshold_uncertainty_score":0.9339361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08239835438761318,"score_gpt":0.3681652381382253,"score_spread":0.2857668837506121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}