{"id":"W2304411857","doi":"10.1002/chem.201600865","title":"Catalyst‐Free Three‐Component Tandem CDC Cyclization: Convenient Access to Isoindolinones from Aromatic Acid, Amides, and DMSO by a Pummerer‐Type Rearrangement","year":2016,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Catalytic C–H Functionalization Methods","field":"Chemistry","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Centers for Disease Control and Prevention; Higher Education Discipline Innovation Project; National Natural Science Foundation of China; Fundamental Research Funds for the Central Universities; National Science Foundation","keywords":"Tandem; Chemistry; Component (thermodynamics); Pummerer rearrangement; Catalysis; Combinatorial chemistry; Organic chemistry; Materials science; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007396627,0.0004225713,0.0004230666,0.00006063607,0.0003005039,0.0004427634,0.0009348919,0.00008878149,0.004929748],"category_scores_gemma":[0.0009300326,0.0003432662,0.0001301703,0.0002481025,0.0001530444,0.0003128986,0.0005941448,0.000306019,0.0001236101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000304139,"about_ca_system_score_gemma":0.00012544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001663393,"about_ca_topic_score_gemma":0.00000581978,"domain_scores_codex":[0.9971529,0.0001211451,0.0009429884,0.0006571027,0.0006880154,0.0004378703],"domain_scores_gemma":[0.9974663,0.0001980447,0.0005551841,0.0008796414,0.0002452098,0.0006555726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001346038,0.0001143554,0.005214137,0.00009107949,0.0002069042,0.0001071249,0.0001585847,0.00001706027,0.9381617,0.000004312506,0.04905497,0.006735152],"study_design_scores_gemma":[0.007641732,0.00007739515,0.007872555,0.00134842,0.0004449526,0.001269711,0.000321972,0.0004644573,0.7574033,0.001023355,0.2206528,0.001479306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9579232,0.001076342,0.03226807,0.002733484,0.0004177637,0.0001584674,0.0002297508,0.0001467098,0.005046247],"genre_scores_gemma":[0.9856343,0.0004743909,0.003833415,0.0008641533,0.002220395,0.00002610043,0.0005780151,0.0001955379,0.006173665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1807584,"threshold_uncertainty_score":0.999902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03582580516397223,"score_gpt":0.2719209181723733,"score_spread":0.2360951130084011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}