{"id":"W2304970776","doi":"10.1182/blood.v122.21.2907.2907","title":"Evaluation Of Afuresertib, An Oral Pan-AKT Inhibitor, In Patients With Langerhans Cell Histiocytosis","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Histiocytic Disorders and Treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Langerhans cell histiocytosis; Medicine; Histiocytosis; Bone marrow; Chemotherapy; Internal medicine; Histiocyte; Gastroenterology; Surgery; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000148652,0.0001001057,0.0001844015,0.00008900429,0.00001961493,0.000006987644,0.00003956787,0.00005283062,0.0002389143],"category_scores_gemma":[0.00003915918,0.00007451574,0.00002433447,0.0001346108,0.00002847107,0.0001013865,0.000009663126,0.00005226929,0.00003944772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007399028,"about_ca_system_score_gemma":0.0001198363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008675287,"about_ca_topic_score_gemma":0.000292701,"domain_scores_codex":[0.9989191,0.0000582587,0.0001699973,0.0001666387,0.0005449196,0.0001411156],"domain_scores_gemma":[0.999333,0.000009406443,0.00006341373,0.0002118212,0.0003126481,0.00006971254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00008800648,0.008418096,0.978531,0.00004234168,0.00007909116,0.000003935037,0.0004592153,0.000007300904,0.0005890748,0.000007096126,0.0001896471,0.01158517],"study_design_scores_gemma":[0.02328512,0.00174219,0.9686269,0.00008065811,0.0007696016,7.846905e-7,0.0001149041,0.000179208,0.004952334,0.00007167166,0.00006666229,0.0001099843],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943279,0.0001012354,0.000002896313,0.00003186164,0.00002764486,0.0006999501,0.000009230106,0.00001497215,0.004784319],"genre_scores_gemma":[0.9992049,0.000002301531,0.0003890362,0.00002882877,0.00001461783,0.0000780621,0.0001096738,0.00001539382,0.0001572335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02319712,"threshold_uncertainty_score":0.3038664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01578302690819292,"score_gpt":0.2484359523670021,"score_spread":0.2326529254588092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}