{"id":"W2305631593","doi":"10.2337/db15-0572","title":"A Regulatory T-Cell Gene Signature Is a Specific and Sensitive Biomarker to Identify Children With New-Onset Type 1 Diabetes","year":2016,"lang":"en","type":"article","venue":"Diabetes","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Prevention of Organ Failure; St. Paul's Hospital; Child and Family Research Institute; McGill University; University of British Columbia","funders":"Canadian Institutes of Health Research; Genome British Columbia","keywords":"Biomarker; FOXP3; Autoimmunity; Immunology; Gene signature; Immune system; Disease; Type 1 diabetes; Autoimmune disease; Pathogenesis; Regulatory T cell; Medicine; Gene; Biology; T cell; Diabetes mellitus; Gene expression; Antibody; IL-2 receptor; Internal medicine; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006981828,0.0004594432,0.0005795665,0.001260259,0.0001504285,0.0005028151,0.0002065891,0.0004514638,0.0007882644],"category_scores_gemma":[0.001039315,0.0001987709,0.0003827171,0.0007472104,0.0002117133,0.0002693238,0.0003040919,0.0004827147,0.0002760584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002275123,"about_ca_system_score_gemma":0.0001795692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004789969,"about_ca_topic_score_gemma":0.0007602626,"domain_scores_codex":[0.9994381,0.0001064205,0.00004250914,0.0001904913,0.0001612733,0.00006112309],"domain_scores_gemma":[0.9993744,0.0001794157,0.0002382918,0.000039313,0.00009308905,0.00007559084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001115023,0.00009948038,0.6667776,0.0001814365,0.0001469395,0.0002663705,0.0001464532,0.0008724861,0.2884116,0.0001414214,0.0005696958,0.04127136],"study_design_scores_gemma":[0.00003168005,0.0007536134,0.9103053,0.00005805625,0.0001824769,0.001835957,0.0001633327,0.004472181,0.07941618,0.0002667487,0.002481738,0.00003270492],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888369,0.001926331,0.007068761,0.00008419163,0.0000273991,0.00004073595,0.001039421,0.0001668978,0.0008095294],"genre_scores_gemma":[0.980346,0.0007037733,0.01718548,0.0001574441,0.00002564636,0.00007101794,0.00096409,0.00002900258,0.0005176428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001260259,"threshold_uncertainty_score":0.003692389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004481961029262921,"score_gpt":0.205789776654021,"score_spread":0.2013078156247581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}