{"id":"W2305631593","doi":"10.2337/db15-0572","title":"A Regulatory T-Cell Gene Signature Is a Specific and Sensitive Biomarker to Identify Children With New-Onset Type 1 Diabetes","year":2016,"lang":"en","type":"article","venue":"Diabetes","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Prevention of Organ Failure; St. Paul's Hospital; Child and Family Research Institute; McGill University; University of British Columbia","funders":"Canadian Institutes of Health Research; Genome British Columbia","keywords":"Biomarker; FOXP3; Autoimmunity; Immunology; Gene signature; Immune system; Disease; Type 1 diabetes; Autoimmune disease; Pathogenesis; Regulatory T cell; Medicine; Gene; Biology; T cell; Diabetes mellitus; Gene expression; Antibody; IL-2 receptor; Internal medicine; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001195588,0.0002616046,0.0002179423,0.00007301574,0.00007755702,0.00005851944,0.0001387225,0.000198009,0.00004080081],"category_scores_gemma":[0.00003840509,0.0001856256,0.0000684588,0.0001836099,0.0001029655,0.00001040324,0.0001205372,0.00006356301,0.00003902412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001415212,"about_ca_system_score_gemma":0.00005164287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004639226,"about_ca_topic_score_gemma":0.000003704057,"domain_scores_codex":[0.9986238,0.00004387752,0.0001457087,0.0005563747,0.0001535774,0.0004766963],"domain_scores_gemma":[0.9992276,0.00002841061,0.00007906416,0.0003418567,0.0001038962,0.0002191667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000235162,0.00003363206,0.2310723,0.000004537635,0.0001725669,3.999685e-7,0.00003503144,5.944594e-7,0.7313256,0.000001963753,0.03334988,0.003979926],"study_design_scores_gemma":[0.0006934019,0.0002452595,0.3270956,0.00003930498,0.000034621,4.913571e-7,0.00002183209,0.000001352396,0.6672473,0.00004998482,0.004266611,0.0003042675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956837,0.003048097,0.00001871933,0.0005632956,0.000082329,0.0002501493,0.0001818826,0.00002588398,0.0001459608],"genre_scores_gemma":[0.9968795,0.0001907797,0.0002565695,0.001329395,0.0001127213,0.00001037489,0.0001303087,0.00004946657,0.001040897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09602329,"threshold_uncertainty_score":0.7569594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004481961029262921,"score_gpt":0.205789776654021,"score_spread":0.2013078156247581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}