{"id":"W2305652353","doi":"10.1016/j.bmc.2016.03.036","title":"Design, synthesis and biological evaluation of 5-amino-4-(1H-benzoimidazol-2-yl)-phenyl-1,2-dihydro-pyrrol-3-ones as inhibitors of protein kinase FGFR1","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Tobacco Research Unit","funders":"National Academy of Sciences of Ukraine","keywords":"Chemistry; Fibroblast growth factor receptor 1; IC50; Docking (animal); Stereochemistry; Kinase; Amino acid; Protein kinase A; Biochemistry; In vitro; Fibroblast growth factor; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002734144,0.0004224122,0.0002898299,0.0002995729,0.0001993268,0.0003479138,0.0005386716,0.0002992293,0.001629551],"category_scores_gemma":[0.0002133317,0.000255661,0.000274156,0.0001445992,0.0001629658,0.0002113474,0.0001612296,0.0003746634,0.000578122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004434112,"about_ca_system_score_gemma":0.0004365807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000873473,"about_ca_topic_score_gemma":0.002235447,"domain_scores_codex":[0.9998716,0.00002493062,0.00001076439,0.00002002967,0.00002967918,0.0000429777],"domain_scores_gemma":[0.9999287,0.000008914381,0.00002471562,0.000005574925,0.00001504242,0.00001704171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007451593,0.0004417798,0.0002198233,0.0003803066,0.00003391437,0.0002530449,0.00009031455,0.003778177,0.9698741,0.001129747,0.0005652074,0.02248843],"study_design_scores_gemma":[0.000589105,0.004390151,0.001619692,0.00002261481,0.00008961691,0.0003908649,0.00003282362,0.003668119,0.9750386,0.0001173188,0.01400992,0.00003120228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9606367,0.01089482,0.01474002,0.0004057241,0.0001404061,0.0008751893,0.001353088,0.0002994571,0.0106545],"genre_scores_gemma":[0.975901,0.00574162,0.009711687,0.0001129735,0.00002977175,0.0002660026,0.001033625,0.00002711778,0.007176194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001629551,"threshold_uncertainty_score":0.005451441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03731524653592396,"score_gpt":0.2841370624865872,"score_spread":0.2468218159506632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}