{"id":"W2305652353","doi":"10.1016/j.bmc.2016.03.036","title":"Design, synthesis and biological evaluation of 5-amino-4-(1H-benzoimidazol-2-yl)-phenyl-1,2-dihydro-pyrrol-3-ones as inhibitors of protein kinase FGFR1","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Tobacco Research Unit","funders":"National Academy of Sciences of Ukraine","keywords":"Chemistry; Fibroblast growth factor receptor 1; IC50; Docking (animal); Stereochemistry; Kinase; Amino acid; Protein kinase A; Biochemistry; In vitro; Fibroblast growth factor; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001341174,0.0003162336,0.0004078117,0.00006336668,0.00005819622,0.000008693848,0.0003500395,0.0004610582,0.0005625964],"category_scores_gemma":[0.003066882,0.0002185375,0.00009843329,0.000190445,0.0007195315,0.00001049004,0.0002354349,0.0001452193,0.00001012072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006881582,"about_ca_system_score_gemma":0.0004448578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003153876,"about_ca_topic_score_gemma":0.000001673567,"domain_scores_codex":[0.9973398,0.0002535447,0.0005514807,0.0006289954,0.0008233913,0.0004027453],"domain_scores_gemma":[0.9983405,0.0001578824,0.0003020302,0.0005340496,0.0004383974,0.0002270636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003580402,0.0001259581,0.0018209,0.0002876088,0.00008789138,0.000004852368,0.00003908083,6.501946e-7,0.9915961,0.000004328671,0.0001311279,0.005543429],"study_design_scores_gemma":[0.001142097,0.0004955443,0.0019646,0.000380374,0.000074664,0.00004014613,0.0001415989,0.00002234392,0.9951296,0.0001274269,0.0002328141,0.0002487839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964609,0.002075666,0.0003031529,0.0002965615,0.00004313233,0.000521561,0.00003914366,0.00001815511,0.0002417907],"genre_scores_gemma":[0.9990006,0.0002101563,0.0002609856,0.00001491501,0.0002376427,0.00008098112,0.00002238501,0.00003694649,0.0001354063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005294646,"threshold_uncertainty_score":0.89117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03731524653592396,"score_gpt":0.2841370624865872,"score_spread":0.2468218159506632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}