{"id":"W2306189957","doi":"10.1038/srep23608","title":"Prohibitin-induced, obesity-associated insulin resistance and accompanying low-grade inflammation causes NASH and HCC","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Manitoba Health Research Council","keywords":"Insulin resistance; Adipose tissue; Endocrinology; Internal medicine; Prohibitin; Inflammation; Fatty liver; Downregulation and upregulation; Nonalcoholic fatty liver disease; Pathogenesis; Steatohepatitis; Genetically modified mouse; Medicine; Obesity; Biology; Mitochondrion; Transgene; Disease; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009209782,0.0002400594,0.0001744443,0.000329105,0.0001396839,0.0001912377,0.00008273524,0.0001334606,0.001044602],"category_scores_gemma":[0.00007757878,0.00009340245,0.0001289094,0.0001897952,0.000223252,0.0001274536,0.0001981547,0.0003579352,0.000169997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001565202,"about_ca_system_score_gemma":0.0001402742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003111126,"about_ca_topic_score_gemma":0.0008443563,"domain_scores_codex":[0.9999321,0.00001054035,0.000006453777,0.00001295356,0.00002205198,0.00001600701],"domain_scores_gemma":[0.9999019,0.000006190282,0.0000471977,0.000009037576,0.000006854345,0.0000287673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004235688,0.00008533443,0.005433827,0.00008675665,0.00001887815,0.0004846222,0.00002226723,0.0000416653,0.9872534,0.0003298441,0.0001230223,0.005696886],"study_design_scores_gemma":[0.00006411707,0.0011095,0.1913734,0.00003147115,0.0001152487,0.009031728,0.0001754055,0.001228005,0.7867696,0.0005631419,0.00951834,0.00002005043],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929428,0.00303102,0.001871869,0.0001417142,0.00002716061,0.00001618898,0.0001552328,0.00006578879,0.001748286],"genre_scores_gemma":[0.9950191,0.001693776,0.000897065,0.00005599384,0.00001837976,0.00001591496,0.0002204167,0.00000836134,0.002071022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001044602,"threshold_uncertainty_score":0.003494561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01691568449261383,"score_gpt":0.2521225966164348,"score_spread":0.235206912123821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}