{"id":"W2306667279","doi":"10.1128/jcm.02700-15","title":"Seeded Amplification of Chronic Wasting Disease Prions in Nasal Brushings and Recto-anal Mucosa-Associated Lymphoid Tissues from Elk by Real-Time Quaking-Induced Conversion","year":2016,"lang":"en","type":"article","venue":"Journal of Clinical Microbiology","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Food Inspection Agency","funders":"National Institute of Allergy and Infectious Diseases; National Park Service; National Institutes of Health; National Center for Research Resources; National Institute of Neurological Disorders and Stroke; Merial; Canadian Food Inspection Agency; Colorado State University","keywords":"Chronic wasting disease; Pathology; Immunohistochemistry; Mucous membrane of nose; Medicine; Biopsy; Biology; Disease; Scrapie","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006832188,0.000236096,0.0001720432,0.0003034724,0.0001408456,0.0004205038,0.0001830378,0.0002868281,0.0003625831],"category_scores_gemma":[0.0009646781,0.0001711433,0.0001590153,0.0001333951,0.0003203902,0.0001694604,0.0001924898,0.0002471007,0.0001727184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002046233,"about_ca_system_score_gemma":0.0001150062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001198991,"about_ca_topic_score_gemma":0.002716286,"domain_scores_codex":[0.9994425,0.0000918635,0.00006115158,0.0001844349,0.0001528768,0.00006723044],"domain_scores_gemma":[0.9993545,0.0002477964,0.0001547678,0.00008502644,0.0001287785,0.00002914445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001017864,0.0000223504,0.01253342,0.00003264772,0.000008733656,0.0000585746,0.0001012238,0.00006555248,0.9853065,0.00001509173,0.000009502062,0.001744667],"study_design_scores_gemma":[0.00001821306,0.0009492274,0.2551643,0.00002697707,0.00008187672,0.001050032,0.0004117527,0.005176064,0.7357177,0.00006234308,0.001323381,0.00001804228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955205,0.0002531635,0.003586887,0.00001052358,0.000007358361,0.00004658729,0.000117046,0.00002653363,0.0004313642],"genre_scores_gemma":[0.9896923,0.000265883,0.008733585,0.00004775293,0.000005830105,0.00007179037,0.0005551452,0.00001122296,0.0006165919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001198991,"threshold_uncertainty_score":0.003613234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02028346676672936,"score_gpt":0.3188197500898702,"score_spread":0.2985362833231408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}