{"id":"W2306697938","doi":"10.1212/wnl.84.14_supplement.p7.211","title":"Safety and Immunogenicity of Two Dosing Frequencies of Subcutaneous Interferon (scIFN) β-1a in Patients with a First Clinical Demyelinating Event (FCDE): 5-year Results of Phase III, Double-blind, Multicenter Trials (REFLEX/REFLEXION) (P7.211)","year":2015,"lang":"en","type":"article","venue":"Neurology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Medicine; Immunogenicity; Dosing; Multicenter study; Double blind; Clinical trial; Subcutaneous injection; Pediatrics; Internal medicine; Randomized controlled trial; Pathology; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00367144,0.0007949197,0.001148772,0.0003032054,0.0002781564,0.0005463241,0.0004533062,0.0010194,0.001159879],"category_scores_gemma":[0.002367896,0.0003262982,0.001180694,0.000208438,0.000621988,0.0005845307,0.0002151809,0.001841617,0.0002837738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005091779,"about_ca_system_score_gemma":0.0005555344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003644516,"about_ca_topic_score_gemma":0.0004080072,"domain_scores_codex":[0.9989315,0.0006614302,0.00007898211,0.0001269406,0.00009215118,0.0001090676],"domain_scores_gemma":[0.99803,0.0005435052,0.000843903,0.000142796,0.0001068985,0.0003329521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8639936,0.02301499,0.0144645,0.0004103616,0.001107389,0.00008891814,0.0001710053,0.0008917218,0.02126687,0.00008028076,0.0005707297,0.07393968],"study_design_scores_gemma":[0.2718915,0.6960456,0.02522635,0.00003607677,0.0006627988,0.0001740676,0.00005108868,0.0008602071,0.004515846,0.00006589461,0.0004485776,0.00002193783],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979411,0.001247013,0.0001889891,0.00006237598,0.00003133531,0.0001768949,0.00009345364,0.0000185578,0.0002403149],"genre_scores_gemma":[0.9978309,0.0005085611,0.0004168369,0.000161995,0.00008525592,0.0003487765,0.0002995153,0.000005117034,0.0003430276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00367144,"threshold_uncertainty_score":0.01941663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05510147632002247,"score_gpt":0.3483346800343178,"score_spread":0.2932332037142953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}