{"id":"W2306800765","doi":"10.1186/s13041-016-0215-5","title":"Regulation of LRRK2 promoter activity and gene expression by Sp1","year":2016,"lang":"en","type":"article","venue":"Molecular Brain","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; University of Pittsburgh","keywords":"LRRK2; Transcriptional regulation; Gene; Biology; Transcription (linguistics); Promoter; Neurodegeneration; Regulation of gene expression; Transcription factor; Genetics; Translational regulation; Gene expression; Cell biology; Molecular biology; Messenger RNA; Translation (biology); Medicine; Disease; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002094107,0.0003203093,0.0002141161,0.0001943541,0.0001388322,0.000225714,0.0001801228,0.0001966908,0.001507083],"category_scores_gemma":[0.0002432213,0.0001126163,0.0002521569,0.0001264142,0.0002787189,0.000147027,0.0001710082,0.0005399454,0.0004183967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002947845,"about_ca_system_score_gemma":0.0002031509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003350657,"about_ca_topic_score_gemma":0.0004930325,"domain_scores_codex":[0.9998103,0.0000299498,0.00001533987,0.00006292543,0.00004639189,0.00003517632],"domain_scores_gemma":[0.9998084,0.00006635895,0.00004447322,0.00001334002,0.00003372218,0.0000338228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001457784,0.00002562081,0.0003551717,0.00003931033,0.000002956443,0.00003700722,0.00002823626,0.00006121555,0.9977649,0.0001087319,0.00004628718,0.001384658],"study_design_scores_gemma":[0.0000322408,0.0003084551,0.006572771,0.00002390316,0.00001535671,0.0003377819,0.00006946362,0.002409398,0.9880855,0.0001987428,0.001938923,0.000007456194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853408,0.002501491,0.009796952,0.0001720683,0.0000422396,0.00002879326,0.0006052157,0.00009042821,0.00142194],"genre_scores_gemma":[0.9877968,0.0006998661,0.008688947,0.00005431273,0.00001931147,0.00006058144,0.001324825,0.00002628808,0.001329087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001507083,"threshold_uncertainty_score":0.005041659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007890533280976721,"score_gpt":0.244885552245571,"score_spread":0.2369950189645942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}