{"id":"W2307546987","doi":"10.1080/2162402x.2015.1084463","title":"The presence of CXCR4<sup>+</sup>CD1a<sup>+</sup>cells at onset of Langerhans cell histiocytosis is associated with a less favorable outcome","year":2015,"lang":"en","type":"article","venue":"OncoImmunology","topic":"Histiocytic Disorders and Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Leids Universitair Medisch Centrum; Stichting Kinderen Kankervrij; Universiteit Leiden; Deutsches Krebsforschungszentrum","keywords":"Langerhans cell histiocytosis; Histiocyte; CXCR4; Histiocytosis; Pathology; Medicine; Cancer research; Bone marrow; Chemokine; Biology; Molecular biology; Immunology; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002013658,0.0001780576,0.0001743898,0.0003542477,0.0002050548,0.0002477296,0.0001157741,0.0002272216,0.004509934],"category_scores_gemma":[0.0005057293,0.00005993015,0.00008959326,0.0001353165,0.0002958245,0.0001374252,0.000146576,0.000286507,0.0002719274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001644375,"about_ca_system_score_gemma":0.0001297095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002607517,"about_ca_topic_score_gemma":0.0002767918,"domain_scores_codex":[0.9999082,0.00002263686,0.000008994075,0.00002209136,0.00001555069,0.00002263104],"domain_scores_gemma":[0.9995468,0.00008788532,0.0002066807,0.00002576024,0.00002625709,0.0001065007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001639432,0.00007691133,0.9584341,0.00003667788,0.00003545553,0.0005378668,0.00004432039,0.00008444584,0.03201007,0.00004749286,0.000114124,0.006939017],"study_design_scores_gemma":[0.00002809328,0.0005431942,0.9899254,0.000008223044,0.0000491574,0.003752201,0.00007789524,0.0003082039,0.004902806,0.00007255347,0.0003282125,0.000004082762],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995347,0.0001000505,0.00007459614,0.00001398277,0.000002251311,0.000002855153,0.00004128947,0.000004133921,0.0002260862],"genre_scores_gemma":[0.9996986,0.00001939131,0.0000572004,0.000008664529,0.000007648491,0.000002622656,0.00006198703,9.448963e-7,0.0001429823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004509934,"threshold_uncertainty_score":0.01508719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03356550537872877,"score_gpt":0.2673946211698069,"score_spread":0.2338291157910781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}