{"id":"W2307546987","doi":"10.1080/2162402x.2015.1084463","title":"The presence of CXCR4<sup>+</sup>CD1a<sup>+</sup>cells at onset of Langerhans cell histiocytosis is associated with a less favorable outcome","year":2015,"lang":"en","type":"article","venue":"OncoImmunology","topic":"Histiocytic Disorders and Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Leids Universitair Medisch Centrum; Stichting Kinderen Kankervrij; Universiteit Leiden; Deutsches Krebsforschungszentrum","keywords":"Langerhans cell histiocytosis; Histiocyte; CXCR4; Histiocytosis; Pathology; Medicine; Cancer research; Bone marrow; Chemokine; Biology; Molecular biology; Immunology; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004358459,0.0003337573,0.0009654745,0.0001427143,0.0001782492,0.00001258249,0.0003602987,0.0002846593,0.0001747724],"category_scores_gemma":[0.0003269585,0.0002261512,0.0001718141,0.0003991405,0.0006779298,0.00006938871,0.0001570523,0.000283399,0.0001358335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006116715,"about_ca_system_score_gemma":0.0005490393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002259793,"about_ca_topic_score_gemma":0.000256115,"domain_scores_codex":[0.9976349,0.0002329746,0.0006572189,0.0004186058,0.0004937542,0.0005625742],"domain_scores_gemma":[0.9975862,0.0005064143,0.0004575291,0.0008831556,0.0004215156,0.0001451874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.009898449,0.0108039,0.798808,0.0007750784,0.006909055,0.0009240916,0.04115196,0.00441137,0.007615266,0.0005746723,0.1074657,0.01066251],"study_design_scores_gemma":[0.1622008,0.04290899,0.08791689,0.003775587,0.01323681,0.001230443,0.08487289,0.03741658,0.1650722,0.001851394,0.3942842,0.005233225],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983694,0.002032614,0.00004526682,0.0009236182,0.00009806162,0.0005863199,0.0002553902,0.00005574479,0.01230902],"genre_scores_gemma":[0.9704898,0.000218381,0.0002915003,0.0001892497,0.00001600919,0.00006620323,0.0001172301,0.00004934053,0.0285623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7108911,"threshold_uncertainty_score":0.922218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03356550537872877,"score_gpt":0.2673946211698069,"score_spread":0.2338291157910781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}