{"id":"W2307617681","doi":"10.1186/s12977-016-0253-1","title":"The interferon-induced antiviral protein PML (TRIM19) promotes the restriction and transcriptional silencing of lentiviruses in a context-specific, isoform-specific fashion","year":2016,"lang":"en","type":"article","venue":"Retrovirology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Canadian Institutes of Health Research; Université du Québec à Trois-Rivières","keywords":"Promyelocytic leukemia protein; Biology; Gene isoform; Virus latency; Virology; Gene silencing; Viral replication; Cell culture; Interferon; Gene knockdown; SAMHD1; Gene; Transcription factor; Virus; RNA; Nuclear protein; Genetics; Reverse transcriptase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001611029,0.0002413336,0.0001741711,0.0002060263,0.0001252921,0.0004100724,0.0002091904,0.0001855328,0.00136997],"category_scores_gemma":[0.0001005887,0.0001236641,0.0002496844,0.000123602,0.0001948187,0.0001509394,0.000259853,0.000514762,0.0004849785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003014691,"about_ca_system_score_gemma":0.0001630763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002807744,"about_ca_topic_score_gemma":0.000448744,"domain_scores_codex":[0.9998772,0.00001575158,0.00001280314,0.00003337906,0.00003157747,0.00002932719],"domain_scores_gemma":[0.9998887,0.00001750662,0.00003740613,0.00002126264,0.00001175863,0.00002338748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003907472,0.00000924529,0.00009723661,0.00001555065,0.000002852268,0.00002160139,0.000007768367,0.00002174973,0.9989488,0.00007052686,0.00002228773,0.000743425],"study_design_scores_gemma":[0.00001043603,0.0001023961,0.00176084,0.000006069916,0.00001266539,0.0001519121,0.00001341371,0.0005018062,0.9945516,0.00003946639,0.002847661,0.000001661522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988273,0.003269112,0.004867853,0.00008926632,0.0000383822,0.00003662455,0.0004133076,0.0001591286,0.002853407],"genre_scores_gemma":[0.9928019,0.001034979,0.002477893,0.00004643628,0.00001559562,0.00002532486,0.000597382,0.00004016633,0.002960294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00136997,"threshold_uncertainty_score":0.004583061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02109838611628067,"score_gpt":0.2298534073862241,"score_spread":0.2087550212699434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}