{"id":"W2307846193","doi":"10.18433/j38g7x","title":"Coupling Genotyping and Computational Modeling in Prediction of Anti-epileptic Drugs that cause Stevens Johnson Syndrome and Toxic Epidermal Necrolysis for Carrier of HLA-B*15:02","year":2016,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Carbamazepine; Toxic epidermal necrolysis; Oxcarbazepine; Lamotrigine; Phenytoin; Primidone; Epilepsy; Medicine; Phenobarbital; Genotyping; Pharmacology; Dermatology; Genotype; Genetics; Biology; Psychiatry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003397354,0.0004241493,0.000620021,0.0005023305,0.0002580089,0.0005984241,0.0004008961,0.0004526737,0.001468686],"category_scores_gemma":[0.001485357,0.0002576519,0.0007502625,0.0003390339,0.0001152431,0.0002603231,0.0002625133,0.0003208273,0.0001933123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003404946,"about_ca_system_score_gemma":0.0008797055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006971295,"about_ca_topic_score_gemma":0.005923795,"domain_scores_codex":[0.9998639,0.00006644268,0.00001139675,0.00002204181,0.00001818279,0.00001800765],"domain_scores_gemma":[0.9995311,0.0003195913,0.0000660142,0.00001738688,0.00003196881,0.00003399021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0005663867,0.0003143153,0.06909098,0.0001112193,0.0003500416,0.0004121058,0.00003759457,0.9097649,0.00166207,0.001042433,0.001055523,0.01559242],"study_design_scores_gemma":[0.00003867759,0.00008154942,0.00383528,0.000009217694,0.00006993183,0.00007536652,0.00002232281,0.9944533,0.0003051891,0.0008638467,0.0002385139,0.000006801591],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9718841,0.0007446489,0.02335439,0.0006357619,0.00004662319,0.00005123794,0.0007149959,0.0003055636,0.002262708],"genre_scores_gemma":[0.9916176,0.0001903438,0.007052934,0.0001005808,0.00001337404,0.00003387497,0.0006030819,0.00002032761,0.0003678632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006971295,"threshold_uncertainty_score":0.01386142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1235183764863898,"score_gpt":0.3852340277826578,"score_spread":0.2617156512962679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}