{"id":"W2307897282","doi":"10.1021/acs.biochem.5b01203","title":"Substrate and pH-Dependent Kinetic Profile of 3-Mercaptopropionate Dioxygenase from <i>Pseudomonas aeruginosa</i>","year":2016,"lang":"en","type":"article","venue":"Biochemistry","topic":"Metal-Catalyzed Oxygenation Mechanisms","field":"Chemistry","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Deprotonation; Chemistry; Protonation; Cysteine; Thiol; Substrate (aquarium); Dioxygenase; Sulfinic acid; Tyrosine; Stereochemistry; Biochemistry; Enzyme; Organic chemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001359496,0.000323841,0.0003355862,0.00003845574,0.00005552614,0.00002723929,0.0003586672,0.0002614497,0.003642051],"category_scores_gemma":[0.0001341404,0.0002502022,0.0001069358,0.00009442948,0.0001680189,0.00009299498,0.0001619297,0.000139008,0.00008620416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006259415,"about_ca_system_score_gemma":0.00009461593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007307789,"about_ca_topic_score_gemma":0.000003047965,"domain_scores_codex":[0.9979947,0.0000192203,0.0005122701,0.0006647444,0.0004714613,0.0003376124],"domain_scores_gemma":[0.9984742,0.000110248,0.0003068754,0.0007377837,0.0001392156,0.0002317204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005456646,0.00008454608,0.0005506121,0.0001805013,0.00006587597,0.00001990809,0.00003381365,2.699911e-7,0.9959932,0.0001372126,0.0002184537,0.00266102],"study_design_scores_gemma":[0.001311498,0.00001117341,0.0003166951,0.0001481819,0.00004534641,0.00002238333,0.0000777414,0.00002631039,0.9967037,0.0006758836,0.0003221917,0.0003388899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927034,0.0009711965,0.0002170407,0.0001337102,0.00009446212,0.0001022302,0.0009818908,0.0001036133,0.004692452],"genre_scores_gemma":[0.993442,0.0001739108,0.001260216,0.00003004124,0.0001788783,0.00005180396,0.0002238139,0.00004542694,0.004593888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003555847,"threshold_uncertainty_score":0.999995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01053116115279158,"score_gpt":0.211591270264929,"score_spread":0.2010601091121375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}