{"id":"W2308190790","doi":"10.1093/hmg/ddw086","title":"Failure to up-regulate transcription of genes necessary for muscle adaptation underlies limb girdle muscular dystrophy 2A (calpainopathy)","year":2016,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Muscular Dystrophy Canada","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Biology; Limb-girdle muscular dystrophy; Skeletal muscle; Muscular dystrophy; Cell biology; Endocrinology; Gene; Internal medicine; Genetics; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001961123,0.000255622,0.0002173355,0.0001422936,0.000147039,0.00002761282,0.0001867917,0.000240777,0.00002956329],"category_scores_gemma":[0.00004170608,0.0002208727,0.0002750537,0.0001317904,0.0001122917,0.000008860882,0.00005399058,0.00004346727,0.000006368678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003079279,"about_ca_system_score_gemma":0.00006032066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008924836,"about_ca_topic_score_gemma":0.0000574608,"domain_scores_codex":[0.9984118,0.0001155572,0.0004072881,0.0005068181,0.0002623462,0.0002962019],"domain_scores_gemma":[0.9988964,0.00001182367,0.0001498034,0.0005003791,0.000301184,0.0001403746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001347167,0.00006498571,0.00006777854,0.00007071435,0.00006788677,0.000001165806,0.0000971001,0.003099929,0.9784266,0.0005585153,0.0004181204,0.01699243],"study_design_scores_gemma":[0.001697415,0.001347877,0.005609869,0.00006329455,0.0001045878,0.000005709963,0.0002059504,0.0005693798,0.9478808,0.001177809,0.04090817,0.000429158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6146371,0.0007013055,0.3836036,0.0002419051,0.000154975,0.0005738976,0.00003969791,0.00002213411,0.00002542128],"genre_scores_gemma":[0.9911459,0.00009677283,0.007314701,0.0001735903,0.0002087793,0.000124314,0.000229145,0.00006742669,0.000639385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3765088,"threshold_uncertainty_score":0.9006926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01668719904717045,"score_gpt":0.2430087848053962,"score_spread":0.2263215857582258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}