{"id":"W2308348317","doi":"10.1161/atvb.34.suppl_1.351","title":"Abstract 351: Development of an Engineered Base Cerebrovasculature Model to Study Alzheimer’s Disease in vitro","year":2014,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Cerebral amyloid angiopathy; Blood–brain barrier; LRP1; Interstitial fluid; Pathology; Amyloid (mycology); Cerebral arteries; Glymphatic system; Parenchyma; Lymphatic system; Clearance; Central nervous system; Neuroscience; Medicine; Disease; Biology; Dementia; Cerebrospinal fluid; LDL receptor; Internal medicine; Lipoprotein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003818476,0.0004935114,0.0004218207,0.0003162312,0.0002811736,0.0005405386,0.0004069461,0.000522681,0.000955796],"category_scores_gemma":[0.0001691654,0.0002161608,0.0005643758,0.0002425899,0.0001773367,0.0003134266,0.0003014869,0.0008326946,0.0007881697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003620222,"about_ca_system_score_gemma":0.0003040852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001567631,"about_ca_topic_score_gemma":0.001567218,"domain_scores_codex":[0.9997634,0.00003154026,0.00002579542,0.00004842947,0.00008349528,0.00004737035],"domain_scores_gemma":[0.999845,0.00002189786,0.0000280849,0.00002380567,0.00004087958,0.00004023406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005212543,0.00006845156,0.0001340433,0.0000685251,0.000008207558,0.0001129351,0.00004836213,0.0002623073,0.9972761,0.0003477826,0.0001658533,0.001455352],"study_design_scores_gemma":[0.00003001081,0.000601007,0.002221681,0.00003148233,0.00006637394,0.0004578966,0.00004374834,0.005275065,0.9776804,0.0002518345,0.01331779,0.00002286894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9130438,0.005483015,0.06602401,0.0004576618,0.0006333888,0.0003751366,0.002567207,0.0006486138,0.01076727],"genre_scores_gemma":[0.9453011,0.003830754,0.03983221,0.00023912,0.00008289007,0.0004974394,0.003006281,0.000105821,0.007104357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001567631,"threshold_uncertainty_score":0.003197432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05938023923899977,"score_gpt":0.3248175823882297,"score_spread":0.26543734314923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}