{"id":"W2308417652","doi":"10.1002/gcc.22360","title":"Epigenetic mediated silencing of EYA4 contributes to tumorigenesis in oral dysplastic cells","year":2016,"lang":"en","type":"article","venue":"Genes Chromosomes and Cancer","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Occupational Cancer Research Centre","funders":"Canadian Institutes of Health Research","keywords":"Carcinogenesis; Cancer research; DNA methylation; Cancer; Dysplasia; Epigenetics; Gene silencing; Biology; Medicine; Carcinoma in situ; Pathology; Gene; Internal medicine; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001320212,0.0002064575,0.0001907286,0.0002338204,0.0001589324,0.0003551643,0.0001404429,0.0001842434,0.001130584],"category_scores_gemma":[0.000143758,0.0001211462,0.000178229,0.0001693759,0.0001878178,0.0001489043,0.0003424152,0.0002081009,0.0004493897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002137196,"about_ca_system_score_gemma":0.0001709854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006142287,"about_ca_topic_score_gemma":0.000617647,"domain_scores_codex":[0.9999163,0.00001270167,0.000008116837,0.0000218595,0.00002548333,0.00001545715],"domain_scores_gemma":[0.9999431,0.000006903489,0.00002404442,0.000008546715,0.000009131109,0.000008130265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003709233,0.000006014943,0.001198613,0.00002513014,0.000005863583,0.00007885472,0.00001529862,0.0000600365,0.9961559,0.0001031485,0.00002865002,0.002285443],"study_design_scores_gemma":[0.0000095897,0.0001354709,0.06699492,0.000009719049,0.00004236152,0.0008982139,0.0001033843,0.001500051,0.9205258,0.000237838,0.009533808,0.000008813079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894021,0.004407349,0.003392058,0.000104959,0.00001827414,0.00001452363,0.0002924194,0.00007847397,0.002289805],"genre_scores_gemma":[0.994024,0.001536687,0.0009461963,0.00003028301,0.000004695863,0.00001336143,0.0002737916,0.00001317475,0.00315768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001130584,"threshold_uncertainty_score":0.003782153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006021444401362683,"score_gpt":0.2355962589216696,"score_spread":0.2295748145203069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}