{"id":"W2308714960","doi":"10.1158/0008-5472.can-15-2128","title":"Ovarian Cancers Harboring Inactivating Mutations in <i>CDK12</i> Display a Distinct Genomic Instability Pattern Characterized by Large Tandem Duplications","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Genomic variations and chromosomal abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Genome instability; Cancer research; Biology; Genetics; Tandem repeat; BRCA2 Protein; Mutation; DNA damage; DNA; Germline mutation; Gene; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005557114,0.0001330125,0.000145976,0.00007627288,0.0002912372,0.00004965691,0.0002562799,0.00009616269,0.0001675898],"category_scores_gemma":[0.0001023925,0.0001108201,0.00004785635,0.0002228649,0.000121498,0.00001992615,0.0001811145,0.0001725688,0.00001187502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005660998,"about_ca_system_score_gemma":0.0004874777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001690935,"about_ca_topic_score_gemma":0.002681838,"domain_scores_codex":[0.9984047,0.0001713827,0.0002864956,0.0004441485,0.000178191,0.0005150427],"domain_scores_gemma":[0.9992279,0.00006705735,0.00007767438,0.0003690371,0.000154176,0.0001041667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00003308988,0.00005591544,0.1836675,0.00002466766,0.00002441053,0.000001037792,0.0002028468,0.000005039268,0.8113177,0.0001327484,0.0001109899,0.004424067],"study_design_scores_gemma":[0.003677809,0.0001724645,0.6358876,0.000192339,0.00001855343,0.000006183922,0.0008385988,0.00008007294,0.2533751,0.0002933659,0.1047852,0.0006726338],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938703,0.0002297914,0.003587085,0.0007552678,0.00006878202,0.0004333007,0.000719211,0.00001241719,0.0003238411],"genre_scores_gemma":[0.9974159,0.0002092295,0.00004011483,0.00006200169,0.00020945,0.00123255,0.0001633997,0.00002611652,0.0006412183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5579426,"threshold_uncertainty_score":0.4519114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02480011645584609,"score_gpt":0.3177420023494144,"score_spread":0.2929418858935683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}