{"id":"W2308714960","doi":"10.1158/0008-5472.can-15-2128","title":"Ovarian Cancers Harboring Inactivating Mutations in <i>CDK12</i> Display a Distinct Genomic Instability Pattern Characterized by Large Tandem Duplications","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Genomic variations and chromosomal abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Genome instability; Cancer research; Biology; Genetics; Tandem repeat; BRCA2 Protein; Mutation; DNA damage; DNA; Germline mutation; Gene; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000792495,0.0001632094,0.0001758742,0.0005548045,0.0001157749,0.0002621313,0.00009480155,0.0001032535,0.001349909],"category_scores_gemma":[0.0002384953,0.00006730281,0.0001057012,0.0002987671,0.0002188622,0.00008716321,0.0001533124,0.0001410328,0.0002160297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001398219,"about_ca_system_score_gemma":0.00008010267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008349344,"about_ca_topic_score_gemma":0.00115733,"domain_scores_codex":[0.99993,0.000008792977,0.000007161216,0.00001993675,0.00001527688,0.00001877233],"domain_scores_gemma":[0.9998586,0.00002856156,0.00005999479,0.00001429044,0.00001331031,0.0000251665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000955749,0.0000333564,0.2826658,0.00006752472,0.00005410108,0.002412747,0.0001113685,0.0002485346,0.6882936,0.0002825358,0.0002679411,0.02460682],"study_design_scores_gemma":[0.00001723257,0.0001623517,0.9081191,0.000005059519,0.00004422198,0.013318,0.0001229795,0.0004733634,0.07479966,0.0001476257,0.002785093,0.000005270192],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976574,0.0005493113,0.0005404194,0.00001817562,0.000002338141,0.000004646114,0.0002508962,0.00003731793,0.0009394462],"genre_scores_gemma":[0.9991409,0.0001407236,0.0002365163,0.000008099737,0.000002371268,0.000002756125,0.0002007426,0.00000658394,0.0002612771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001349909,"threshold_uncertainty_score":0.004515827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02480011645584609,"score_gpt":0.3177420023494144,"score_spread":0.2929418858935683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}