{"id":"W2309020081","doi":"10.1126/science.aac4750","title":"Designer protein delivery: From natural to engineered affinity-controlled release systems","year":2016,"lang":"en","type":"review","venue":"Science","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":183,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Covalent bond; Chemistry; Molecule; Controlled release; Matrix (chemical analysis); Biophysics; Nanotechnology; Combinatorial chemistry; Salt (chemistry); Materials science; Organic chemistry; Chromatography; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001053309,0.0004448289,0.001990674,0.0005644949,0.0002324661,0.0001417863,0.0008635472,0.0001692065,0.0001748598],"category_scores_gemma":[0.00123886,0.0002316207,0.0004387753,0.001026884,0.0003442959,0.0001407672,0.000281676,0.0005487356,0.001883984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003121311,"about_ca_system_score_gemma":0.001993909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002264388,"about_ca_topic_score_gemma":0.000004589226,"domain_scores_codex":[0.9961486,0.0001918746,0.0006046441,0.0008450608,0.001412617,0.0007972441],"domain_scores_gemma":[0.9975718,0.0004813905,0.0001655146,0.0006510649,0.0003832557,0.0007469943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007534486,0.00009510178,0.000003349667,0.005509713,0.0002243436,0.0003469526,0.0000515466,0.000001152317,0.004118418,0.0004908768,0.001583826,0.9868213],"study_design_scores_gemma":[0.001058384,0.0001844824,0.00001431871,0.02195802,0.0001659524,0.00005248653,0.000007264944,0.0001048689,0.0001051036,0.00001494582,0.9759752,0.0003590274],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001215982,0.9927064,0.00005738421,0.0002914074,0.0006701277,0.003928216,0.0001510382,0.00006974841,0.0009097431],"genre_scores_gemma":[0.002001981,0.9707958,0.0008282875,0.0001070257,0.0009180522,0.0005804575,0.00003873172,0.00004479903,0.02468484],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9864622,"threshold_uncertainty_score":0.9988931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0484676025661985,"score_gpt":0.3551470906273038,"score_spread":0.3066794880611052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}