{"id":"W2309020081","doi":"10.1126/science.aac4750","title":"Designer protein delivery: From natural to engineered affinity-controlled release systems","year":2016,"lang":"en","type":"review","venue":"Science","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":183,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Covalent bond; Chemistry; Molecule; Controlled release; Matrix (chemical analysis); Biophysics; Nanotechnology; Combinatorial chemistry; Salt (chemistry); Materials science; Organic chemistry; Chromatography; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006613951,0.0008083793,0.001112509,0.001676234,0.0001717968,0.001011853,0.0009909373,0.001078439,0.001362622],"category_scores_gemma":[0.0003677794,0.0004115069,0.00042663,0.001373644,0.0005901364,0.001173595,0.0006945447,0.001346765,0.001437358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00071787,"about_ca_system_score_gemma":0.000440026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004218971,"about_ca_topic_score_gemma":0.0004457542,"domain_scores_codex":[0.9997721,0.00003259451,0.00002482494,0.0000506184,0.00009361182,0.00002635054],"domain_scores_gemma":[0.9999018,0.00004168619,0.00002107643,0.000005317357,0.00002009331,0.0000100024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001099781,0.0001615841,0.0002023727,0.01973298,0.0001166612,0.0004758179,0.0001595705,0.001432452,0.04387359,0.02026801,0.00980499,0.903662],"study_design_scores_gemma":[0.00003523342,0.0002270945,0.0003900545,0.001372972,0.0000881189,0.001387935,0.00004104527,0.0004126029,0.01542399,0.002952792,0.9776319,0.00003623183],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001132362,0.9936829,0.002634935,0.0002239029,0.0001334004,0.00002453699,0.00003573401,0.00003914132,0.002093117],"genre_scores_gemma":[0.00509025,0.9902726,0.00262867,0.0002413778,0.00007825546,0.00004379321,0.00005609298,0.000009152685,0.001579813],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001676234,"threshold_uncertainty_score":0.005208492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0484676025661985,"score_gpt":0.3551470906273038,"score_spread":0.3066794880611052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}