{"id":"W2309034916","doi":"10.1074/jbc.r115.677211","title":"Amyloid Precursor Protein (APP) Metabolites APP Intracellular Fragment (AICD), Aβ42, and Tau in Nuclear Roles","year":2015,"lang":"en","type":"review","venue":"Journal of Biological Chemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Senile plaques; Amyloid precursor protein; Intracellular; Nucleus; Alzheimer's disease; Amyloid (mycology); Tau pathology; Chemistry; P3 peptide; Neuroscience; Tau protein; Cell biology; Biochemistry; Molecular biology; Biology; Disease; Pathology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003796706,0.0007815686,0.001277484,0.002376145,0.0003780107,0.0009626379,0.0007037665,0.0008088278,0.004666223],"category_scores_gemma":[0.0004197863,0.0002739697,0.0004251654,0.002049679,0.000376894,0.001124179,0.0006848322,0.001343964,0.003754338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005189442,"about_ca_system_score_gemma":0.001016988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001020954,"about_ca_topic_score_gemma":0.001886344,"domain_scores_codex":[0.9998772,0.00001858494,0.00002067389,0.00002105701,0.00004716279,0.00001527073],"domain_scores_gemma":[0.9998341,0.00004719571,0.00002713835,0.000006123165,0.00006048842,0.00002501936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001044414,0.00009974627,0.0002303783,0.01960763,0.00008659595,0.0003298314,0.00009175343,0.0002686513,0.003892035,0.004854928,0.02929726,0.9411368],"study_design_scores_gemma":[0.00001076237,0.00005781226,0.0006260198,0.001485428,0.00006768297,0.0009944323,0.00004711462,0.00004727002,0.0006464754,0.001325925,0.9946791,0.00001199539],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001876305,0.9978771,0.0001299911,0.000215038,0.0001716024,0.000007384212,0.00002738794,0.000008773921,0.001375126],"genre_scores_gemma":[0.0008667721,0.9976826,0.0002310893,0.00009842466,0.0001012863,0.000008031551,0.00003315698,0.000001403011,0.0009772711],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004666223,"threshold_uncertainty_score":0.01561004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04944071866539507,"score_gpt":0.3308077034284966,"score_spread":0.2813669847631016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}