{"id":"W2309442902","doi":"10.1016/j.jalz.2016.02.002","title":"Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria","year":2016,"lang":"en","type":"review","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":1904,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas Mental Health University Institute; University of British Columbia","funders":"Janssen Pharmaceuticals; Engineering and Physical Sciences Research Council; McDonnell Center for Systems Neuroscience; University of California, San Diego; Genentech; National Institutes of Health; National Institute of General Medical Sciences; H. Lundbeck A/S; Servier; Avid Radiopharmaceuticals; Université Pierre et Marie Curie; Fujirebio Europe; Vetenskapsrådet; Eisai; Agence Nationale de la Recherche; EU Joint Programme – Neurodegenerative Disease Research; National Institute on Aging; National Institute for Health and Care Research; Center for Innovative Medicine; Northern California Institute for Research and Education; Association France Parkinson; Danone; Fondation Brain Canada; Les Laboratories Pierre Fabre; AXA Research Fund; Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques; Pfizer; Biogen; AstraZeneca; Eli Lilly and Company; Tau Consortium; Bristol-Myers Squibb; Sanofi; Economic and Social Research Council; TauRx Pharmaceuticals; Canadian Institutes of Health Research; Ipsen; Bundesinstitut für Arzneimittel und Medizinprodukte; Alzheimer's Association; Fondation pour la Recherche sur Alzheimer; Ministero della Salute; Amgen; California Institute for Regenerative Medicine","keywords":"Natural history; Disease; Natural (archaeology); Medicine; History; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1003371552872701,"score_gpt":0.3910229828399583,"score_spread":0.2906858275526882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}