{"id":"W2309770165","doi":"10.1126/science.aaf1328","title":"SCS macrophages suppress melanoma by restricting tumor-derived vesicle–B cell interactions","year":2016,"lang":"en","type":"article","venue":"Science","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":346,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; Boehringer Ingelheim Fonds; Deutsche Forschungsgemeinschaft; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; European Molecular Biology Organization","keywords":"Lymph; Immune system; Melanoma; Extracellular vesicles; Cancer research; Population; Tumor cells; Tumor microenvironment; Microvesicles; Biology; Immunology; Cell biology; Medicine; Pathology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001902023,0.0002690863,0.0002031297,0.0002364361,0.0001244872,0.0002681735,0.0001505655,0.0002640898,0.0009053914],"category_scores_gemma":[0.0001091002,0.0001205988,0.0002136438,0.00006760107,0.0003104542,0.000144978,0.0002262593,0.0004547503,0.0003024392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001334693,"about_ca_system_score_gemma":0.0002139643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003790536,"about_ca_topic_score_gemma":0.0006732604,"domain_scores_codex":[0.9998535,0.00003770872,0.00001049421,0.00002406615,0.00003184576,0.00004240939],"domain_scores_gemma":[0.999871,0.00001973878,0.00003707321,0.00001761724,0.0000118986,0.00004266221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001597586,0.00003753671,0.0002307458,0.00001406639,0.000003423856,0.00003422806,0.00001356653,0.00005335511,0.9982109,0.0001793886,0.00002709499,0.001035887],"study_design_scores_gemma":[0.00004789467,0.0006219889,0.001923354,0.000005334327,0.00001239332,0.0002106483,0.00004469155,0.0009440914,0.9934338,0.0001472429,0.002605861,0.000002747257],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951088,0.0008365733,0.002390752,0.0001096268,0.00002614011,0.0000288438,0.00007985466,0.00007273458,0.001346656],"genre_scores_gemma":[0.9961656,0.0002869949,0.001449174,0.00003311809,0.000008371878,0.00002247754,0.0000587104,0.00002017483,0.001955385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009053914,"threshold_uncertainty_score":0.00302887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0059322035472247,"score_gpt":0.2476432058681895,"score_spread":0.2417110023209648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}