{"id":"W2309963042","doi":"10.1128/jvi.00322-16","title":"Both Epistasis and Diversifying Selection Drive the Structural Evolution of the Ebola Virus Glycoprotein Mucin-Like Domain","year":2016,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Ebola virus; Biology; Epistasis; Ebolavirus; Evolutionary biology; Viral evolution; Outbreak; Context (archaeology); Negative selection; Virology; Lineage (genetic); Selection (genetic algorithm); Clade; Genetics; Molecular evolution; Phylogenetics; Gene; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003267811,0.000220214,0.0001600274,0.0001988374,0.0003875753,0.0005864023,0.0003335191,0.0004028101,0.001404127],"category_scores_gemma":[0.0009075882,0.0001268195,0.0002664603,0.0002539769,0.0003590988,0.0005154308,0.0006609902,0.0005834508,0.0002843837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004749876,"about_ca_system_score_gemma":0.0002434106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001186334,"about_ca_topic_score_gemma":0.002083641,"domain_scores_codex":[0.9998661,0.00003501745,0.000009194235,0.00003315654,0.00002752488,0.00002898866],"domain_scores_gemma":[0.9996828,0.00008755601,0.0001224471,0.00003111704,0.0000386273,0.00003754513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003457041,0.00006442575,0.1250429,0.0001525698,0.000136958,0.0007429282,0.0003949108,0.00319594,0.841186,0.003326766,0.0004461631,0.02496476],"study_design_scores_gemma":[0.00009528943,0.0008705624,0.6987593,0.0001283188,0.0004279815,0.004901671,0.001643369,0.08776883,0.1729658,0.009248836,0.02305671,0.0001332321],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948534,0.0004500475,0.00311859,0.0001570833,0.00001145517,0.000005741092,0.00006094107,0.00003049247,0.001312147],"genre_scores_gemma":[0.9976103,0.0002048529,0.001735281,0.00009185122,0.000008659046,0.00000400878,0.0001012965,0.0000092597,0.0002345177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001404127,"threshold_uncertainty_score":0.004697323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01167149433044151,"score_gpt":0.2779407994519917,"score_spread":0.2662693051215502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}