{"id":"W2310172832","doi":"10.1038/ncomms11112","title":"Individual heritable differences result in unique cell lymphocyte receptor repertoires of naïve and antigen-experienced cells","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Center for Research Resources; U.S. National Library of Medicine; National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; National Institute on Drug Abuse; U.S. Public Health Service; National Institutes of Health","keywords":"Antigen; Receptor; Biology; Lymphocyte; T-cell receptor; T lymphocyte; Immunology; Genetics; Cell; Immune system; Cell biology; Computational biology; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003486592,0.000152081,0.0002200574,0.0004127926,0.000142937,0.0004646502,0.0001847437,0.0002158592,0.001053109],"category_scores_gemma":[0.0007611303,0.0001564541,0.0001364169,0.0002775682,0.0003097665,0.0001948442,0.000421716,0.0003137112,0.0001908348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001362742,"about_ca_system_score_gemma":0.00008665751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002844791,"about_ca_topic_score_gemma":0.0006427137,"domain_scores_codex":[0.9996131,0.00007457432,0.00002415688,0.000136647,0.00009246547,0.00005903287],"domain_scores_gemma":[0.9994085,0.0002014936,0.0001793847,0.0001017981,0.00004237843,0.00006634297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001647043,0.00002048475,0.02277245,0.00001586596,0.00003082093,0.00005158842,0.00007300634,0.0001362694,0.9718175,0.0001822256,0.00001807235,0.004717048],"study_design_scores_gemma":[0.0000109939,0.0003978439,0.7553558,0.000009389267,0.00009501373,0.001065458,0.0002181604,0.001573264,0.2398358,0.0005125329,0.0009014058,0.00002431986],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983577,0.0001274939,0.001017783,0.000006272082,0.000002155292,0.000002845683,0.00008726742,0.00001034859,0.0003880966],"genre_scores_gemma":[0.9987406,0.00008414272,0.0007852859,0.00001314296,0.000002780562,0.000006449832,0.0001143337,0.00001592157,0.0002373514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001053109,"threshold_uncertainty_score":0.003522933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01511917747959106,"score_gpt":0.2533628698664317,"score_spread":0.2382436923868406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}