{"id":"W2310172832","doi":"10.1038/ncomms11112","title":"Individual heritable differences result in unique cell lymphocyte receptor repertoires of naïve and antigen-experienced cells","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Center for Research Resources; U.S. National Library of Medicine; National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; National Institute on Drug Abuse; U.S. Public Health Service; National Institutes of Health","keywords":"Antigen; Receptor; Biology; Lymphocyte; T-cell receptor; T lymphocyte; Immunology; Genetics; Cell; Immune system; Cell biology; Computational biology; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002086814,0.0001191889,0.0001970221,0.0001423093,0.0001781522,0.00001237096,0.0005121766,0.0003978365,0.0003034089],"category_scores_gemma":[0.0001427802,0.0000853156,0.00004093674,0.0001861693,0.0003611265,0.0001735653,0.0002264355,0.0004118767,0.00004240908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000504604,"about_ca_system_score_gemma":0.00006734944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001872502,"about_ca_topic_score_gemma":0.0001655673,"domain_scores_codex":[0.9989506,0.0003251614,0.0003275002,0.0001932428,0.00003585566,0.0001676475],"domain_scores_gemma":[0.9985179,0.0004199939,0.0001706726,0.0007627576,0.0001135595,0.00001508077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001022371,0.00015292,0.0051168,0.000005376305,0.00002414696,1.284836e-7,0.001284992,1.27158e-7,0.9841732,0.0007415239,0.005817431,0.002581099],"study_design_scores_gemma":[0.001084589,0.0001119153,0.02016828,0.0001000741,0.000008695204,0.000006045924,0.001535981,0.000002978182,0.8058546,0.000035686,0.1709481,0.0001430482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748928,0.01856535,0.0000260208,0.001155089,0.0009873321,0.0002123218,0.00003489027,0.00004591922,0.004080291],"genre_scores_gemma":[0.9866114,0.009061234,0.0004831881,0.000124623,0.000006304042,0.00003174193,0.00006539185,0.000008876344,0.003607252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1783186,"threshold_uncertainty_score":0.3479069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01511917747959106,"score_gpt":0.2533628698664317,"score_spread":0.2382436923868406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}