{"id":"W2310558151","doi":"10.1152/ajpgi.00299.2014","title":"Blocking peripheral serotonin synthesis by telotristat etiprate (LX1032/LX1606) reduces severity of both chemical- and infection-induced intestinal inflammation","year":2015,"lang":"en","type":"article","venue":"American Journal of Physiology-Gastrointestinal and Liver Physiology","topic":"Gastrointestinal motility and disorders","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute; Health Sciences Centre","funders":"Canadian Institutes of Health Research; Multidisciplinary University Research Initiative","keywords":"Inflammation; Colitis; Proinflammatory cytokine; Immunology; Immune system; Cytokine; Medicine; Myeloperoxidase; Inflammatory bowel disease; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001098172,0.0003791535,0.0004720004,0.0002461071,0.00009763511,0.000186135,0.0002457117,0.0004256731,0.001961307],"category_scores_gemma":[0.00009986078,0.0001515142,0.000243053,0.0001426252,0.0002170965,0.0001999767,0.0001448929,0.0008911518,0.00038753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000125595,"about_ca_system_score_gemma":0.0001868306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003687874,"about_ca_topic_score_gemma":0.0007840243,"domain_scores_codex":[0.9999007,0.00001851638,0.00001447798,0.00001415096,0.00002185324,0.00003035377],"domain_scores_gemma":[0.9998804,0.00001183564,0.00004100899,0.000008073454,0.000008525665,0.00005006765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001754181,0.0003169224,0.0002501171,0.0001246485,0.00001519601,0.00006372833,0.00001565722,0.00006405982,0.9928804,0.00004539706,0.00007114992,0.004398547],"study_design_scores_gemma":[0.0006590002,0.02029233,0.01031404,0.00002804283,0.00009387927,0.0006074246,0.00007691825,0.0009829268,0.9642028,0.0000560814,0.002672273,0.00001427792],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961979,0.001439103,0.0009167807,0.0001356063,0.00003236779,0.00003978747,0.0003266587,0.0001190149,0.0007926392],"genre_scores_gemma":[0.9935588,0.00171522,0.001317724,0.0000880916,0.00002196668,0.00007485925,0.0006979936,0.00001638332,0.002508979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001961307,"threshold_uncertainty_score":0.006561279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01539539753227186,"score_gpt":0.2480329521221281,"score_spread":0.2326375545898562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}