{"id":"W2310762461","doi":"10.4049/jimmunol.184.supp.144.7","title":"Molecular characterization of the interaction between the rheumatoid arthritis shared epitope and calreticulin (144.7)","year":2010,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Calreticulin; Binding site; Epitope; Docking (animal); Mutant; Innate immune system; Mutagenesis; Site-directed mutagenesis; Biology; Endoplasmic reticulum; Plasma protein binding; Chemistry; Cell biology; Receptor; Biochemistry; Genetics; Antibody; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001154909,0.0002386725,0.0002192457,0.0001320343,0.0001197681,0.0001326928,0.0001994135,0.0002611557,0.0008877186],"category_scores_gemma":[0.0001330107,0.00007443638,0.0003289074,0.0001047234,0.00009931908,0.00009373759,0.0001238508,0.0002628481,0.0003774938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002679642,"about_ca_system_score_gemma":0.00009791146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005780532,"about_ca_topic_score_gemma":0.0004971485,"domain_scores_codex":[0.9999093,0.00001901863,0.00000549113,0.0000166889,0.00002752332,0.00002203685],"domain_scores_gemma":[0.9999274,0.00001759202,0.00001699603,0.00000703755,0.00001141,0.00001944552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006772202,0.00001766083,0.0004116016,0.0000119405,0.000005541748,0.00005190031,0.000005168365,0.00005566132,0.9989234,0.00003441391,0.00000980484,0.0004051442],"study_design_scores_gemma":[0.00002551441,0.000264681,0.01800361,0.000006636601,0.00003067712,0.0005674888,0.00004100138,0.004950515,0.9739663,0.00006579647,0.002070506,0.000007314798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974578,0.0004022093,0.001607635,0.00002737876,0.000006523354,0.00000751694,0.0001086099,0.00001061777,0.000371714],"genre_scores_gemma":[0.9959848,0.0001644331,0.002479044,0.00003617117,0.000003014916,0.000008927212,0.0005326307,0.000006207569,0.0007848031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008877186,"threshold_uncertainty_score":0.002969742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01211547872656678,"score_gpt":0.2749017978419525,"score_spread":0.2627863191153857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}