{"id":"W2311016709","doi":"10.1093/hmg/ddw087","title":"Variation at 2q35 (<i>PNKD</i>and<i>TMBIM1</i>) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease","year":2016,"lang":"en","type":"review","venue":"Human Molecular Genetics","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"FP7 Health; National Center for Chronic Disease Prevention and Health Promotion; Kuopion Yliopistollinen Sairaala; National Cancer Institute; Academy of Finland; National Institute on Alcohol Abuse and Alcoholism; Medical Research Council; National Institutes of Health; Centers for Disease Control and Prevention; NordForsk; China Scholarship Council; Jane ja Aatos Erkon Säätiö; Opetus- ja Kulttuuriministeriö; European Commission; Wellcome Trust; University of Southern California; Cancer Research UK; Netherlands eScience Center; National Human Genome Research Institute; Cancer Research Wales; California Department of Public Health; Tenovus; National Institute for Social Care and Health Research; University of Hawai'i; National Institute for Health and Care Research","keywords":"Genome-wide association study; Odds ratio; Colorectal cancer; Linkage disequilibrium; Single-nucleotide polymorphism; Inflammatory bowel disease; SNP; Genetics; Biology; Genetic association; Genetic predisposition; Disease; Medicine; Internal medicine; Cancer; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001961765,0.0008119436,0.001335291,0.0002531188,0.0002844921,0.0001069722,0.0002168927,0.00039045,0.0001099711],"category_scores_gemma":[0.000128036,0.0005664526,0.0002574352,0.0001674144,0.0005586956,0.00004483945,0.0003400824,0.0004307402,0.00002197477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003740674,"about_ca_system_score_gemma":0.0005181318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004548334,"about_ca_topic_score_gemma":0.0001553452,"domain_scores_codex":[0.9967883,0.0004055053,0.0006407825,0.0009916835,0.0006749187,0.0004988717],"domain_scores_gemma":[0.9979948,0.0001876518,0.000580961,0.0006071632,0.0001496214,0.0004797637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.001500531,0.0002149886,0.2931205,0.100282,0.00531674,0.001413182,0.001371789,0.00007298165,0.01496446,0.000134795,0.0004402045,0.5811678],"study_design_scores_gemma":[0.005357164,0.003524836,0.662777,0.03715416,0.02001988,0.0003082844,0.000009818033,0.00004211453,0.001445433,0.0004140055,0.2661218,0.002825492],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.4388451,0.5594503,0.00003072897,0.000008240391,0.0001558357,0.001351943,0.00008053287,0.00004535534,0.00003195237],"genre_scores_gemma":[0.05278622,0.945594,0.0001479035,0.00005894635,0.0002323725,0.0007584306,0.00006131244,0.0001651025,0.0001956716],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5783423,"threshold_uncertainty_score":0.9996787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0103411619500988,"score_gpt":0.2892079552085073,"score_spread":0.2788667932584085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}