{"id":"W2311083859","doi":"10.1038/ng.3531","title":"Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes","year":2016,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":149,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"National Institutes of Health; Biotechnology and Biological Sciences Research Council; Novo Nordisk Fonden; National Institute for Health and Care Research","keywords":"Beta cell; Biology; Genetic predisposition; Nod; Pancreatic islets; Type 1 diabetes; NOD mice; BETA (programming language); Type 2 diabetes; Diabetes mellitus; Immunology; Genetics; Fragility; Islet; Endocrinology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005123201,0.001357229,0.0004856754,0.002167751,0.0005954462,0.0009176115,0.0007724726,0.001697114,0.006457885],"category_scores_gemma":[0.002811159,0.0004384475,0.0006348133,0.001383021,0.0007538879,0.0005614889,0.0009654352,0.001191065,0.0003316828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002494988,"about_ca_system_score_gemma":0.0002276635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008298327,"about_ca_topic_score_gemma":0.00052821,"domain_scores_codex":[0.9993799,0.0001941093,0.00005521236,0.0001514193,0.0001326505,0.00008675941],"domain_scores_gemma":[0.998801,0.0004324399,0.0004386621,0.00009556836,0.00005988208,0.0001724079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003132794,0.0005141087,0.7172549,0.0002875876,0.001116975,0.06165047,0.001032106,0.001013933,0.1735382,0.006139313,0.002337831,0.03198168],"study_design_scores_gemma":[0.0001858383,0.0004644747,0.8681905,0.0002204703,0.001401806,0.09848823,0.0008104662,0.002486923,0.01568095,0.008168458,0.003803491,0.00009831507],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928516,0.001590941,0.00157854,0.0008442182,0.000125047,0.00001592204,0.0003059312,0.00008087868,0.00260685],"genre_scores_gemma":[0.9973907,0.0007740789,0.000777811,0.0001368576,0.0001544682,0.000008472233,0.0001423942,0.00002951296,0.0005857804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006457885,"threshold_uncertainty_score":0.02160382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00984346028777348,"score_gpt":0.2486414400797243,"score_spread":0.2387979797919508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}