{"id":"W2311083859","doi":"10.1038/ng.3531","title":"Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes","year":2016,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":149,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"National Institutes of Health; Biotechnology and Biological Sciences Research Council; Novo Nordisk Fonden; National Institute for Health and Care Research","keywords":"Beta cell; Biology; Genetic predisposition; Nod; Pancreatic islets; Type 1 diabetes; NOD mice; BETA (programming language); Type 2 diabetes; Diabetes mellitus; Immunology; Genetics; Fragility; Islet; Endocrinology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007299723,0.0001204706,0.0001787282,0.00004587297,0.00005215699,0.0000125766,0.00004119033,0.0002648986,0.00007109966],"category_scores_gemma":[0.0001765811,0.00007993833,0.00003369696,0.000117839,0.00007018366,0.00002176691,0.0000225019,0.0001078458,0.00001713588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002687782,"about_ca_system_score_gemma":0.00006271934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":4.653238e-7,"about_ca_topic_score_gemma":9.236642e-7,"domain_scores_codex":[0.9992963,0.00001762348,0.0001336196,0.0002286753,0.0001304899,0.0001933113],"domain_scores_gemma":[0.9991975,0.0001529692,0.00004077116,0.0002239028,0.0002736327,0.0001112337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003701913,0.0001637377,0.6656771,0.0004881156,0.0001273793,0.000001966553,0.00009838052,0.000003247217,0.2868246,0.0001359547,0.01938647,0.02672289],"study_design_scores_gemma":[0.002347585,0.001405754,0.7675058,0.0001095515,0.0003878713,0.000004289461,0.00002847189,0.0003741071,0.1825545,0.001957916,0.04308754,0.0002366658],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851903,0.01204448,0.0002525705,0.0006601701,0.0005127616,0.0003315741,0.00002932462,0.00004672698,0.0009321411],"genre_scores_gemma":[0.9910962,0.0006601321,0.005890754,0.0007554431,0.0002930545,0.00001000539,0.00002826809,0.00001931595,0.001246828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1042701,"threshold_uncertainty_score":0.3259791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00984346028777348,"score_gpt":0.2486414400797243,"score_spread":0.2387979797919508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}