{"id":"W2311181417","doi":"10.1093/cid/ciw020","title":"Ruxolitinib Induces Interleukin 17 and Ameliorates Chronic Mucocutaneous Candidiasis Caused by STAT1 Gain-of-Function Mutation","year":2016,"lang":"en","type":"letter","venue":"Clinical Infectious Diseases","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":83,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Chronic mucocutaneous candidiasis; Medicine; Gain of function; Ruxolitinib; Mutation; Immunology; Mucocutaneous zone; Interleukin; Internal medicine; Cytokine; Gene; Genetics; Disease; Biology; Myelofibrosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002810128,0.0003643644,0.0006124595,0.0001454089,0.0004036835,0.0003440678,0.0003439862,0.001990261,0.00127023],"category_scores_gemma":[0.000698468,0.0001282309,0.000442632,0.00008842392,0.0003429364,0.0003151991,0.0001985057,0.002224354,0.0004755199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004011834,"about_ca_system_score_gemma":0.0002173757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004043845,"about_ca_topic_score_gemma":0.0007691543,"domain_scores_codex":[0.9998077,0.00003548973,0.00002130415,0.00001866883,0.00003859795,0.00007825159],"domain_scores_gemma":[0.9997843,0.0001038545,0.00002737442,0.0000208375,0.00002064505,0.00004298706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.009906953,0.001471533,0.02676322,0.000512722,0.0002652454,0.5199487,0.000314397,0.001352177,0.1738893,0.007119686,0.0760341,0.182422],"study_design_scores_gemma":[0.005926481,0.007201774,0.06942796,0.0002688717,0.0006499184,0.56172,0.000543146,0.01861404,0.1357329,0.009289693,0.1904476,0.0001776061],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8715055,0.0103837,0.002250734,0.08391745,0.006067516,0.00009679334,0.000273617,0.0004654928,0.02503935],"genre_scores_gemma":[0.9772586,0.001537382,0.0007745336,0.01177173,0.00186456,0.00002508917,0.0001219977,0.00001921182,0.006626855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001990261,"threshold_uncertainty_score":0.004249334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01534832433408086,"score_gpt":0.2849445255454801,"score_spread":0.2695962012113993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}