{"id":"W2311181417","doi":"10.1093/cid/ciw020","title":"Ruxolitinib Induces Interleukin 17 and Ameliorates Chronic Mucocutaneous Candidiasis Caused by STAT1 Gain-of-Function Mutation","year":2016,"lang":"en","type":"letter","venue":"Clinical Infectious Diseases","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":83,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Chronic mucocutaneous candidiasis; Medicine; Gain of function; Ruxolitinib; Mutation; Immunology; Mucocutaneous zone; Interleukin; Internal medicine; Cytokine; Gene; Genetics; Disease; Biology; Myelofibrosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0002960198,0.0005594171,0.001066071,0.000251793,0.0003107657,0.00007099828,0.0002838405,0.001486078,0.0007649328],"category_scores_gemma":[0.0006845261,0.0004588223,0.0004120786,0.0001868713,0.001481167,0.0002005828,0.0001277864,0.001421671,0.0002134056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001688598,"about_ca_system_score_gemma":0.0005581453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002972088,"about_ca_topic_score_gemma":0.00001816665,"domain_scores_codex":[0.9962885,0.0008385997,0.001272514,0.0008158565,0.00009910149,0.0006854289],"domain_scores_gemma":[0.996266,0.0020538,0.0009356678,0.0005115572,0.0002035744,0.00002938884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003679065,0.001118347,0.004875533,0.0007337354,0.002640384,0.0001828994,0.0004204288,0.000008550121,0.01042045,0.00006413503,0.8127213,0.1664464],"study_design_scores_gemma":[0.00649722,0.004131801,0.007951029,0.0009008989,0.001704457,0.00008419614,0.0003484255,0.000005582536,0.002408877,0.00210092,0.9723521,0.001514423],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8686365,0.1036832,0.0001911338,0.01791871,0.005104554,0.001032114,0.002215667,0.0004388138,0.0007792689],"genre_scores_gemma":[0.9594181,0.002114117,3.470421e-7,0.03268823,0.0002622038,0.0001056699,0.003009936,0.00007627944,0.002325123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.164932,"threshold_uncertainty_score":0.9998102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01534832433408086,"score_gpt":0.2849445255454801,"score_spread":0.2695962012113993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}