{"id":"W2311196695","doi":"10.1101/041996","title":"A CRISPR screen reveals a WNT7B-FZD5 signaling circuit as a therapeutic opportunity in pancreatic cancer","year":2016,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"CRISPR; Pancreatic cancer; Cancer; Biology; Cancer research; Medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001922684,0.0003538921,0.0002965585,0.0002604175,0.0001909482,0.0003948855,0.0002427496,0.0004728475,0.001602013],"category_scores_gemma":[0.0001549901,0.0001456881,0.0002933714,0.0001534169,0.0002117704,0.0001017273,0.0002767502,0.0004671946,0.000368557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004862531,"about_ca_system_score_gemma":0.000326527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001215384,"about_ca_topic_score_gemma":0.001757499,"domain_scores_codex":[0.9997944,0.00002341634,0.00001978159,0.00004705134,0.00008173416,0.00003362639],"domain_scores_gemma":[0.9999238,0.00002366309,0.00001684988,0.00001103212,0.000007283793,0.00001741064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004262311,0.00001304407,0.0001932511,0.00001932774,0.000007277573,0.0001358301,0.000007098874,0.0001401152,0.9979577,0.0001490765,0.00005800143,0.001276705],"study_design_scores_gemma":[0.000007996723,0.00005710863,0.001050419,0.000002839331,0.00001604195,0.0003386343,0.000008258778,0.001026345,0.9956666,0.00002974055,0.001793044,0.000003039571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9665155,0.000914517,0.02573928,0.0003421933,0.00005027614,0.00009235095,0.001344024,0.0006527305,0.004349077],"genre_scores_gemma":[0.9823058,0.0004014653,0.01323301,0.00009523085,0.0000049656,0.00003159892,0.000672129,0.00005849337,0.003197303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001602013,"threshold_uncertainty_score":0.005359292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02226876669806245,"score_gpt":0.2827150251896252,"score_spread":0.2604462584915628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}