{"id":"W2311594872","doi":"10.1021/acs.bioconjchem.5b00457","title":"Site-Specific Labeling of Protein Lysine Residues and N-Terminal Amino Groups with Indoles and Indole-Derivatives","year":2015,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Lysine; Indole test; Bioconjugation; Side chain; Lysozyme; Combinatorial chemistry; Stereochemistry; Electrophile; Amino acid; Organic chemistry; Biochemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002056559,0.0002604254,0.0001466261,0.00009151136,0.00008699689,0.0001882532,0.0002340548,0.0002701047,0.0005305214],"category_scores_gemma":[0.0001772804,0.0001024143,0.0001943829,0.0001081229,0.0001990821,0.0001988565,0.0001618488,0.0003204049,0.0002675713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002076191,"about_ca_system_score_gemma":0.0001149858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002746285,"about_ca_topic_score_gemma":0.0006550234,"domain_scores_codex":[0.9998878,0.00002272608,0.000008116197,0.0000298906,0.00002577374,0.00002564549],"domain_scores_gemma":[0.9998809,0.00002091244,0.00004134412,0.00002209148,0.00001627701,0.00001832793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001298119,0.00000415026,0.00003854351,0.00001194446,0.000001187987,0.00001735989,0.000006223402,0.00003471055,0.9991975,0.00008314996,0.00000999274,0.000582193],"study_design_scores_gemma":[0.000001951527,0.00005259541,0.000348658,0.000001652002,0.000003289593,0.00007415621,0.000005178827,0.0003090207,0.9979934,0.00002457504,0.001183106,0.000002437662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9594679,0.001060666,0.03670059,0.00009890187,0.00003332043,0.00004061662,0.0001985772,0.0001455035,0.002253907],"genre_scores_gemma":[0.9734894,0.001045731,0.02155545,0.0000884672,0.000009055655,0.00004022603,0.0003172211,0.00004265695,0.00341172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005305214,"threshold_uncertainty_score":0.001774728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03572624163818495,"score_gpt":0.2744876109992551,"score_spread":0.2387613693610701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}