{"id":"W2311619500","doi":"10.1111/adb.12392","title":"Kappa opioid receptor antagonism and chronic antidepressant treatment have beneficial activities on social interactions and grooming deficits during heroin abstinence","year":2016,"lang":"en","type":"article","venue":"Addiction Biology","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"National Institute on Drug Abuse; Agence Nationale de la Recherche","keywords":"κ-opioid receptor; Naltrexone; Antidepressant; Addiction; Abstinence; Psychology; Opioid; Medicine; Heroin; Psychiatry; Social isolation; Pharmacology; Drug; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004627242,0.0002520444,0.0002360084,0.000166938,0.0005128074,0.00004717068,0.00009876921,0.0001073913,0.0002081537],"category_scores_gemma":[0.00004667765,0.0001886903,0.00005573241,0.00008185105,0.000359984,0.0003007055,0.00005637183,0.0001513458,0.00003423871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001970583,"about_ca_system_score_gemma":0.00002956856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006369485,"about_ca_topic_score_gemma":0.00004320733,"domain_scores_codex":[0.9984536,0.0001496488,0.0002598827,0.0006700649,0.00009861282,0.0003681977],"domain_scores_gemma":[0.9993389,0.0002774202,0.0001403736,0.0001474872,0.00001611939,0.00007972874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000104537,0.000071792,0.006116776,0.000005975363,0.000007064125,0.000006247456,0.000237815,9.967378e-7,0.9368264,0.0002434112,0.000015473,0.05636349],"study_design_scores_gemma":[0.001063378,0.0004535388,0.03033399,0.00005449424,0.00002239727,0.0001063797,0.00005613565,0.00001178097,0.9631912,0.0000464416,0.004431482,0.0002288498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978843,0.00006657359,0.00005817231,0.0005718666,0.0006562328,0.0002972116,0.0002200361,0.000129138,0.0001164693],"genre_scores_gemma":[0.9982979,0.000979112,0.00002843175,0.00008969093,0.000315694,0.0001102297,0.000005151065,0.00002623482,0.000147498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05613464,"threshold_uncertainty_score":0.7694567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03588636089139036,"score_gpt":0.2988288366929721,"score_spread":0.2629424758015817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}