{"id":"W2311853726","doi":"10.1126/scitranslmed.aaf4628","title":"Sclerostin: More than a bone formation brake","year":2016,"lang":"en","type":"review","venue":"Science Translational Medicine","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McMaster University; Montreal Children's Hospital","funders":"","keywords":"Sclerostin; Medicine; Internal medicine; Chemistry; Cell biology; Biology; Signal transduction; Wnt signaling pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005041675,0.0002508943,0.0004940887,0.0002007878,0.0001699483,0.00001789202,0.0003460488,0.0001058396,0.0001009693],"category_scores_gemma":[0.0002112227,0.0001512009,0.0001632744,0.0004099427,0.0009883625,0.00002254433,0.00003658645,0.00007755278,0.00003903824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001178281,"about_ca_system_score_gemma":0.0006111255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004268622,"about_ca_topic_score_gemma":0.000004319107,"domain_scores_codex":[0.9981802,0.00004312749,0.000423142,0.0004623058,0.0006101253,0.0002811504],"domain_scores_gemma":[0.999114,0.00003361863,0.0001789257,0.0003392672,0.0001381863,0.0001959507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001279287,0.00002233464,0.000007750971,0.0009992935,0.00001455756,0.000002464937,0.00004128517,5.14505e-7,0.001467238,0.0008209114,0.0009971396,0.9956137],"study_design_scores_gemma":[0.0004057898,0.00005286361,0.0002473079,0.003597093,0.000141399,0.00006256235,0.00001113818,0.00000394557,0.0000700797,0.0002101407,0.9949732,0.0002244631],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005828554,0.9954518,0.001387121,0.000606489,0.0003165466,0.0003487333,0.0001554123,0.00001535887,0.001660261],"genre_scores_gemma":[0.001765631,0.9959716,0.0001933341,0.0001615598,0.0009714979,0.00004199752,0.0005647777,0.00001878407,0.0003108732],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9953893,"threshold_uncertainty_score":0.6165795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04204270361295582,"score_gpt":0.3481325567007623,"score_spread":0.3060898530878065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}