{"id":"W2312357577","doi":"10.1021/cb300345e","title":"Design of a <i>Candida albicans</i> Disaccharide Conjugate Vaccine by Reverse Engineering a Protective Monoclonal Antibody","year":2012,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Glycomics Centre","keywords":"Disaccharide; Epitope; Candida albicans; Chemistry; Conjugate; Mannan; Monoclonal antibody; Biochemistry; Corpus albicans; Mannose; Antibody; Biology; Microbiology; Polysaccharide; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001055077,0.0003285921,0.0001917854,0.0001505057,0.00009555624,0.000290513,0.0004060775,0.0003759115,0.0006565843],"category_scores_gemma":[0.00008887754,0.000182931,0.0002460336,0.00009577361,0.0001265036,0.0001226223,0.0001505199,0.0005658471,0.0004017712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005308024,"about_ca_system_score_gemma":0.0003011608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000888289,"about_ca_topic_score_gemma":0.0008277175,"domain_scores_codex":[0.999917,0.000008201996,0.000005806653,0.00001463478,0.00002201301,0.00003218404],"domain_scores_gemma":[0.9999518,0.000004098019,0.000015375,0.000003279509,0.00001180329,0.00001364185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005496345,0.00004572907,0.00009403941,0.00003334112,0.000004843373,0.00003677708,0.000006704519,0.0007545121,0.9956101,0.0003784627,0.0001065626,0.002873997],"study_design_scores_gemma":[0.00003982161,0.0005720329,0.0004393028,0.0000068698,0.00002192334,0.0001447183,0.000007973183,0.005610186,0.9873876,0.00007213458,0.005691855,0.000005574615],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9178381,0.00131136,0.07322665,0.000516931,0.0001660767,0.000563187,0.0004366416,0.0004308724,0.005510114],"genre_scores_gemma":[0.9490659,0.0009611954,0.04456969,0.0002752322,0.00001957522,0.0002122805,0.0003865191,0.00004430467,0.004465455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000888289,"threshold_uncertainty_score":0.003851295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01074022239552461,"score_gpt":0.2353697829759539,"score_spread":0.2246295605804293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}