{"id":"W2312357577","doi":"10.1021/cb300345e","title":"Design of a <i>Candida albicans</i> Disaccharide Conjugate Vaccine by Reverse Engineering a Protective Monoclonal Antibody","year":2012,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Glycomics Centre","keywords":"Disaccharide; Epitope; Candida albicans; Chemistry; Conjugate; Mannan; Monoclonal antibody; Biochemistry; Corpus albicans; Mannose; Antibody; Biology; Microbiology; Polysaccharide; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001657258,0.0002666075,0.0004519569,0.00002315696,0.00002950387,0.000006215322,0.0002602783,0.0003430984,0.0005924481],"category_scores_gemma":[0.0003522972,0.000243412,0.00009969508,0.0001254184,0.00009681249,0.00007853828,0.0001095677,0.0003018363,0.00001179006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007130035,"about_ca_system_score_gemma":0.00002995028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000623042,"about_ca_topic_score_gemma":1.279101e-7,"domain_scores_codex":[0.9986783,0.00001823185,0.0003707595,0.0003285354,0.0000909178,0.0005132377],"domain_scores_gemma":[0.9989162,0.0003914735,0.0001530588,0.0003069828,0.00004966494,0.0001826362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002043106,0.0001294012,0.001221878,0.00009379097,0.0001184203,0.000002161414,0.00009136952,0.000005398909,0.9974604,0.0000410839,0.0003750841,0.0002567139],"study_design_scores_gemma":[0.0005044323,0.00001762752,0.000008304514,0.00003944968,0.00005241762,0.00002541689,0.00003085969,0.0001524796,0.9967902,0.00007525371,0.002037238,0.0002663227],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970917,0.0004106573,0.001496722,0.0001243317,0.00004725147,0.0001211498,0.0001555925,0.00007109165,0.000481571],"genre_scores_gemma":[0.9987077,0.00004898457,0.0006377791,0.00006710067,0.0001833486,0.00008269273,0.0001675909,0.00002680735,0.00007797695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001662154,"threshold_uncertainty_score":0.9926051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01074022239552461,"score_gpt":0.2353697829759539,"score_spread":0.2246295605804293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}