{"id":"W2312366560","doi":"10.1158/1538-7445.am2012-4872","title":"Abstract 4872: ICGC PedBrain Tumor - Next-generation sequencing identifies novel subgroup-specific mutations and copy number aberrations in medulloblastoma","year":2012,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Medulloblastoma; Biology; Copy-number variation; Genetics; Exome sequencing; Gene; Indel; ATRX; Transcriptome; Cancer; DNA sequencing; Exome; Genome; Somatic evolution in cancer; Somatic cell; Wnt signaling pathway; Mutation; Genotype; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003028743,0.0004054916,0.0003761811,0.0008906034,0.0003426578,0.0005167759,0.0002601294,0.0005744671,0.001814467],"category_scores_gemma":[0.0004001821,0.0001916938,0.0002897597,0.0006137134,0.0001947088,0.0001074426,0.0002833037,0.0003468961,0.0006138357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000410817,"about_ca_system_score_gemma":0.0003683169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003559304,"about_ca_topic_score_gemma":0.007901133,"domain_scores_codex":[0.9997467,0.00001922296,0.00001597489,0.00009540239,0.00009007012,0.00003250475],"domain_scores_gemma":[0.9998484,0.00003904715,0.00003141461,0.00002213196,0.00003153741,0.00002736918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009052543,0.00008398755,0.03664125,0.0003349658,0.0001695127,0.001922295,0.0002453188,0.00105581,0.9234828,0.0001993673,0.004368104,0.03059129],"study_design_scores_gemma":[0.0002103865,0.0007656312,0.6126474,0.0001288463,0.0005498565,0.01814936,0.0002619965,0.0149232,0.3117966,0.0005057908,0.03999218,0.00006878115],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9730752,0.002155406,0.005499749,0.0001984942,0.00004722504,0.0001371235,0.01580104,0.0004854955,0.002600195],"genre_scores_gemma":[0.9462705,0.0009531477,0.01856185,0.0002468655,0.00002970455,0.0001304881,0.03056553,0.0002137963,0.003028241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003559304,"threshold_uncertainty_score":0.007077157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1337280557903369,"score_gpt":0.3778872657351249,"score_spread":0.2441592099447879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}