{"id":"W2312371445","doi":"10.1038/sj.gt.3301602","title":"Designing gene therapy vectors: avoiding immune responses by using tissue-specific promoters","year":2001,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Genetic enhancement; Biology; Immune system; DNA vaccination; Transfection; HBsAg; Antigen; Immunology; Promoter; Molecular biology; Gene; Gene expression; Immunization; Genetics; Hepatitis B virus; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00106383,0.0004842973,0.0003734872,0.0001815409,0.000525036,0.0001366128,0.0006526966,0.0002750189,0.0002492821],"category_scores_gemma":[0.00003077988,0.0004635647,0.0001879413,0.0004046899,0.000177295,0.00001795062,0.00009062872,0.0002960432,0.00003747553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009657376,"about_ca_system_score_gemma":0.0001871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004585955,"about_ca_topic_score_gemma":0.000006134875,"domain_scores_codex":[0.9965261,0.0008175583,0.000454724,0.0008484779,0.0004412912,0.000911856],"domain_scores_gemma":[0.998414,0.00005681027,0.0001677367,0.001010971,0.0001551922,0.0001952578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01068371,0.0001547554,0.0002347341,0.000002942198,0.000189298,0.00002530442,0.0002705701,0.0001411622,0.9405441,6.374435e-7,0.0006095002,0.0471433],"study_design_scores_gemma":[0.002162763,0.00331128,0.0001176749,0.00001455078,0.000004846437,0.00007802696,0.00008130702,0.0000428917,0.9454477,0.00002874333,0.04818743,0.000522801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9327516,0.0600705,0.005888167,0.0001991368,0.000211753,0.0007223077,0.00002682858,0.00007267147,0.00005706232],"genre_scores_gemma":[0.9499073,0.04514051,0.002436012,0.0004344945,0.0007199941,0.0000778896,0.0001720921,0.0001968632,0.0009148237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04757793,"threshold_uncertainty_score":0.9997816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05701211222923673,"score_gpt":0.3240982973623316,"score_spread":0.2670861851330949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}