{"id":"W2312371445","doi":"10.1038/sj.gt.3301602","title":"Designing gene therapy vectors: avoiding immune responses by using tissue-specific promoters","year":2001,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Genetic enhancement; Biology; Immune system; DNA vaccination; Transfection; HBsAg; Antigen; Immunology; Promoter; Molecular biology; Gene; Gene expression; Immunization; Genetics; Hepatitis B virus; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00131023,0.0009508206,0.0006316175,0.0005155919,0.0004596009,0.0009500988,0.0005827761,0.0009897065,0.0005833249],"category_scores_gemma":[0.000862468,0.0005491496,0.0004473558,0.0004010232,0.0008576641,0.001223045,0.0003982767,0.001462732,0.0006493525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004952949,"about_ca_system_score_gemma":0.0006399095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002729053,"about_ca_topic_score_gemma":0.0004205981,"domain_scores_codex":[0.999505,0.0001407499,0.00004417656,0.0000884098,0.0001409939,0.00008057222],"domain_scores_gemma":[0.9996423,0.0001190006,0.00009201479,0.00003161332,0.00006849184,0.00004656754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000072372,0.00004858961,0.0001690684,0.0002220473,0.000007467208,0.00007078206,0.00009357928,0.0005311614,0.9832424,0.004337583,0.0001727949,0.01103216],"study_design_scores_gemma":[0.00002164578,0.0001358432,0.00009961436,0.00002315099,0.0000211277,0.0002009239,0.00002701118,0.001050425,0.9899955,0.0008465573,0.007567666,0.00001056337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.2396435,0.008272715,0.7446673,0.0008542953,0.0003686828,0.0008153112,0.0002065659,0.0006446632,0.00452704],"genre_scores_gemma":[0.4523709,0.01179489,0.5251756,0.000644876,0.00009537582,0.001019965,0.0005697896,0.0003559781,0.007972624],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.00131023,"threshold_uncertainty_score":0.006929219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05701211222923673,"score_gpt":0.3240982973623316,"score_spread":0.2670861851330949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}