{"id":"W2312375518","doi":"10.1158/0008-5472.can-15-1501","title":"PTP1B Deficiency Enables the Ability of a High-Fat Diet to Drive the Invasive Character of PTEN-Deficient Prostate Cancers","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Cegep de Saint Hyacinthe; Université du Québec à Trois-Rivières; McGill University; Hôpital du Sacré-Cœur de Montréal; McGill University Health Centre","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health; Prostate Cancer Canada; U.S. Department of Defense","keywords":"PTEN; Prostate; Character (mathematics); Cancer research; Prostate cancer; Internal medicine; Medicine; Biology; Endocrinology; Oncology; Cancer; Apoptosis; Genetics; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009092203,0.000125692,0.0001660904,0.00004698258,0.0001485036,0.00001655832,0.0007073787,0.00005884314,0.00008615123],"category_scores_gemma":[0.0008701746,0.00005846963,0.00006913006,0.0003212198,0.0009082585,0.00000695979,0.0005312627,0.0001212921,0.000010527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001394405,"about_ca_system_score_gemma":0.000689963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002658864,"about_ca_topic_score_gemma":0.000857759,"domain_scores_codex":[0.9981731,0.0002329895,0.0002531472,0.0004041326,0.0004773699,0.0004592495],"domain_scores_gemma":[0.9980909,0.000182085,0.0001114596,0.0008589592,0.0006774379,0.00007922311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006158134,0.00004071089,0.001870717,0.0000682856,0.00002793819,8.198599e-7,0.0003295075,0.00004034978,0.9877465,0.0009636135,0.004450639,0.003845073],"study_design_scores_gemma":[0.0002992695,0.000553523,0.01266882,0.0001044816,0.00000758962,6.359255e-7,0.0002023437,8.07778e-7,0.9788635,0.0003788411,0.006833091,0.00008709145],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882681,0.005986141,0.00007798935,0.003671165,0.00009370912,0.001140253,0.0006617205,0.000003726716,0.00009721614],"genre_scores_gemma":[0.9975811,0.001127202,0.00002916979,0.00014242,0.00009736483,0.0006916209,0.00001301901,0.00001636881,0.0003017284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0107981,"threshold_uncertainty_score":0.4019425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03077824690191469,"score_gpt":0.331808943596212,"score_spread":0.3010306966942974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}