{"id":"W2312375518","doi":"10.1158/0008-5472.can-15-1501","title":"PTP1B Deficiency Enables the Ability of a High-Fat Diet to Drive the Invasive Character of PTEN-Deficient Prostate Cancers","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Cegep de Saint Hyacinthe; Université du Québec à Trois-Rivières; McGill University; Hôpital du Sacré-Cœur de Montréal; McGill University Health Centre","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health; Prostate Cancer Canada; U.S. Department of Defense","keywords":"PTEN; Prostate; Character (mathematics); Cancer research; Prostate cancer; Internal medicine; Medicine; Biology; Endocrinology; Oncology; Cancer; Apoptosis; Genetics; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001902732,0.0004724478,0.0002629742,0.0006770277,0.0002278195,0.0004562126,0.0003059407,0.000350963,0.002988512],"category_scores_gemma":[0.000138817,0.0003440475,0.0003617719,0.0003130605,0.0003874298,0.0002795481,0.0004162579,0.0009260905,0.0005869279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003193835,"about_ca_system_score_gemma":0.0003479868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001042233,"about_ca_topic_score_gemma":0.001670442,"domain_scores_codex":[0.9997534,0.00003395784,0.00002252206,0.0000455361,0.00008088276,0.00006368207],"domain_scores_gemma":[0.9998198,0.00002538957,0.00005287086,0.00002273728,0.000008237365,0.00007088998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001716489,0.00007398454,0.00029414,0.00002190883,0.000007780583,0.0001036304,0.00001224347,0.000104656,0.9975546,0.0003740232,0.00006032957,0.001221183],"study_design_scores_gemma":[0.00004746496,0.0004755173,0.005867555,0.00001159617,0.00002794209,0.0009234874,0.00003167108,0.001490884,0.9881046,0.000164286,0.002845529,0.000009504823],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912915,0.0008601026,0.003893513,0.0001573598,0.00003606486,0.00004311835,0.0009035202,0.0002388312,0.00257607],"genre_scores_gemma":[0.9883951,0.001141174,0.003320883,0.00004640008,0.00001161403,0.00005003918,0.000984574,0.00008375688,0.005966341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002988512,"threshold_uncertainty_score":0.009997606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03077824690191469,"score_gpt":0.331808943596212,"score_spread":0.3010306966942974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}