{"id":"W2312381581","doi":"10.1016/j.str.2016.03.005","title":"Paring Down HIV Env: Design and Crystal Structure of a Stabilized Inner Domain of HIV-1 gp120 Displaying a Major ADCC Target of the A32 Region","year":2016,"lang":"en","type":"article","venue":"Structure","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal; Université du Québec à Montréal","funders":"Canadian Institutes of Health Research; National Institutes of Health; Canada Foundation for Innovation; Fonds de Recherche du Québec - Santé; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Epitope; Antibody-dependent cell-mediated cytotoxicity; Context (archaeology); Antibody; Chemistry; Virology; Monoclonal antibody; Biology; Protein structure; Human immunodeficiency virus (HIV); Stereochemistry; Cell biology; Molecular biology; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001190925,0.0002345188,0.00020289,0.0000790195,0.0002177034,0.0003547311,0.0003859197,0.000229373,0.0005172256],"category_scores_gemma":[0.0001412059,0.0001488048,0.0001099631,0.0001161868,0.0001520404,0.0001353854,0.0001202707,0.0006545724,0.0001529448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005245276,"about_ca_system_score_gemma":0.0004130219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001262619,"about_ca_topic_score_gemma":0.00165815,"domain_scores_codex":[0.9999526,0.000005116839,0.00000260871,0.000009596342,0.00002073399,0.000009362813],"domain_scores_gemma":[0.9999741,0.000003908312,0.000004868019,0.000002355358,0.000004798383,0.000009891098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001352796,0.0001422097,0.0007320385,0.00007196754,0.00001308672,0.000142271,0.00003845351,0.003846333,0.9909093,0.0006704814,0.0002539513,0.003044751],"study_design_scores_gemma":[0.0002067331,0.0004298529,0.002936398,0.00001294736,0.00002989792,0.0004987445,0.00006521126,0.04117575,0.9479023,0.0002457906,0.006481381,0.00001496032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944956,0.0004863455,0.003639965,0.00009397777,0.00001308331,0.00003403396,0.0001604911,0.00004538461,0.001031147],"genre_scores_gemma":[0.9812126,0.0006294649,0.01508422,0.00006407122,0.000007492053,0.00004027571,0.0009945496,0.0000236937,0.001943645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001262619,"threshold_uncertainty_score":0.003805697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007975916967859428,"score_gpt":0.2182697252746595,"score_spread":0.2102938083068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}