{"id":"W2312494660","doi":"10.1021/bi401502x","title":"Lobe-Specific Calmodulin Binding to Different Ryanodine Receptor Isoforms","year":2014,"lang":"en","type":"article","venue":"Biochemistry","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Ryanodine receptor; Calmodulin; Ryanodine receptor 2; RYR1; Endoplasmic reticulum; Gene isoform; Isothermal titration calorimetry; Chemistry; Biophysics; Binding site; Skeletal muscle; Malignant hyperthermia; Biochemistry; Allosteric regulation; Cell biology; Receptor; Biology; Endocrinology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000786309,0.0001850212,0.0003137368,0.00004210091,0.0000817895,0.00001107126,0.00007892661,0.0001667909,0.0003841826],"category_scores_gemma":[0.00009223606,0.0001447495,0.0001501027,0.0001288654,0.000051348,0.00001494783,0.00005797842,0.0002197813,0.0005424368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001060123,"about_ca_system_score_gemma":0.00002577956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001626343,"about_ca_topic_score_gemma":1.436801e-7,"domain_scores_codex":[0.9989579,0.00001348762,0.0001838184,0.0003591084,0.0001475834,0.0003381307],"domain_scores_gemma":[0.9992366,0.00003572888,0.00004189903,0.0003988416,0.00004420375,0.0002427708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001949031,0.00005659091,0.000480951,0.00005218071,0.00002915481,0.00001205921,0.00002563505,0.000002580694,0.975932,0.00004386971,0.01831958,0.004850491],"study_design_scores_gemma":[0.0006343104,0.0001908564,0.00249311,0.00008451456,0.00002083266,0.00008208476,0.00002281221,0.00003072495,0.9728272,0.000025035,0.0233908,0.0001977373],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995234,0.0001725403,0.0002466008,0.001137011,0.0002628892,0.0001387063,0.00001316967,0.00008699721,0.002708071],"genre_scores_gemma":[0.9925898,0.00004943936,0.0003757344,0.0004176042,0.001440045,0.00002261848,0.0001321262,0.00002373565,0.004948853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005071213,"threshold_uncertainty_score":0.6972108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008442138041747128,"score_gpt":0.2337777194971411,"score_spread":0.225335581455394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}