{"id":"W2312494660","doi":"10.1021/bi401502x","title":"Lobe-Specific Calmodulin Binding to Different Ryanodine Receptor Isoforms","year":2014,"lang":"en","type":"article","venue":"Biochemistry","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Ryanodine receptor; Calmodulin; Ryanodine receptor 2; RYR1; Endoplasmic reticulum; Gene isoform; Isothermal titration calorimetry; Chemistry; Biophysics; Binding site; Skeletal muscle; Malignant hyperthermia; Biochemistry; Allosteric regulation; Cell biology; Receptor; Biology; Endocrinology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001684302,0.0002155261,0.0003277267,0.000126181,0.0001527701,0.0001684075,0.0002557091,0.0003085001,0.001795624],"category_scores_gemma":[0.0003337125,0.0001114082,0.0002931355,0.000102306,0.0001685923,0.0001392494,0.0001781405,0.0002991083,0.0002786153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000214499,"about_ca_system_score_gemma":0.00009246733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00138367,"about_ca_topic_score_gemma":0.00168612,"domain_scores_codex":[0.9997612,0.00004064858,0.00001396963,0.00006502188,0.00006509106,0.00005410388],"domain_scores_gemma":[0.9998722,0.00002929155,0.00002600875,0.00001063816,0.00002551377,0.00003634908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001466248,0.0000108893,0.0006026109,0.00003139369,0.000007313365,0.00002190143,0.00001561463,0.00007592685,0.9983768,0.00004290739,0.00004564815,0.0006223434],"study_design_scores_gemma":[0.00004712228,0.0002849632,0.07303663,0.00001412823,0.00003345092,0.0004813106,0.00006399011,0.005663757,0.9176938,0.0001131743,0.002550181,0.00001744669],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961613,0.0008406589,0.001618051,0.00005768908,0.00001734956,0.00001844177,0.0002069295,0.00001836966,0.001061203],"genre_scores_gemma":[0.9963728,0.0002786373,0.001682563,0.0001121632,0.000008271282,0.00001972429,0.0003764028,0.00001324753,0.001136143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001795624,"threshold_uncertainty_score":0.006006956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008442138041747128,"score_gpt":0.2337777194971411,"score_spread":0.225335581455394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}