{"id":"W2312504486","doi":"10.1158/1538-7445.am2011-752","title":"Abstract 752: A CCR4 antagonist combined with protein-or DNA-based vaccines efficiently breaks tolerance and elicits CD8+T cells directed against self and viral associated tumor antigens","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Antigen; Immunology; Cytotoxic T cell; DNA vaccination; CCR4; CD8; Biology; Immune system; Chemokine; Chemokine receptor; Immunization","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001125573,0.0004832094,0.0003699762,0.0002028896,0.0001041971,0.0002434345,0.0002343726,0.0003594819,0.002951764],"category_scores_gemma":[0.00008385647,0.0001356684,0.0002357264,0.0001115779,0.000139217,0.0001462196,0.0001512287,0.000664835,0.0006646348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002034052,"about_ca_system_score_gemma":0.0002773183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004595772,"about_ca_topic_score_gemma":0.0007306986,"domain_scores_codex":[0.9998217,0.00003261289,0.00001141902,0.00002460142,0.00004019316,0.00006947034],"domain_scores_gemma":[0.9999473,0.000007875468,0.00001011922,0.000005359029,0.000006782509,0.00002257574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002650294,0.0001526995,0.00006379673,0.00005604446,0.00001177576,0.00002428025,0.000006242538,0.000102101,0.9974765,0.00005472562,0.0001761961,0.001610568],"study_design_scores_gemma":[0.000115854,0.002763574,0.0008247017,0.000008115516,0.00003693183,0.0001117342,0.00001113005,0.0005931063,0.992347,0.00002030392,0.003162813,0.000004746695],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992912,0.001733906,0.002122875,0.0001721829,0.0001470207,0.00007359663,0.0003545524,0.0001122585,0.002371605],"genre_scores_gemma":[0.9895101,0.0009044805,0.002423293,0.0001802604,0.0000620375,0.00008427666,0.0007880221,0.00002497281,0.006022586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002951764,"threshold_uncertainty_score":0.009874642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02664362101442815,"score_gpt":0.2872788679702987,"score_spread":0.2606352469558705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}