{"id":"W2312535998","doi":"10.1021/bc100209r","title":"Conjugation of Synthetic <i>N</i>-Acetyl-Lactosamine to Azide-Containing Proteins Using the Staudinger Ligation","year":2010,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Glycomics Centre; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Glycomics Centre","keywords":"Chemistry; Glycan; Epitope; Glycoconjugate; Glycoprotein; Azide; Biochemistry; Staudinger reaction; Combinatorial chemistry; Stereochemistry; Antigen; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004753691,0.0001978785,0.0001716347,0.00003881283,0.0001524574,0.00005321101,0.0003171416,0.0002193809,0.0001604027],"category_scores_gemma":[0.0004803657,0.0001632837,0.00009380313,0.0002064887,0.0001778499,0.00000968401,0.0001600771,0.0002453448,0.00001222158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002223738,"about_ca_system_score_gemma":0.0001610506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006127209,"about_ca_topic_score_gemma":0.00002520853,"domain_scores_codex":[0.9986147,0.0000426036,0.0003524856,0.0003936257,0.0002888754,0.0003077588],"domain_scores_gemma":[0.9987404,0.00002434133,0.0001851579,0.0006071874,0.0003001401,0.0001428113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001292923,0.0000393778,0.0007435932,0.00006443558,0.00002723388,9.643044e-7,0.0000667675,0.00005534465,0.9980913,0.00008066097,0.00008717175,0.000613806],"study_design_scores_gemma":[0.0004068608,0.0001219295,0.0002701977,0.00003824214,0.00001336895,0.00001770954,0.000151844,0.0003142015,0.9893247,0.00004763893,0.00909843,0.0001948531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952778,0.00005594061,0.001891136,0.0004927553,0.00009306356,0.0006968803,0.00002967112,0.00001937282,0.001443345],"genre_scores_gemma":[0.9975146,0.00001102683,0.001312891,0.0001381039,0.000280737,0.00008911824,0.0000897975,0.00003289962,0.0005308475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009011258,"threshold_uncertainty_score":0.6658517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01677480674203246,"score_gpt":0.2847074988895927,"score_spread":0.2679326921475602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}