{"id":"W2312539884","doi":"10.3899/jrheum.101038","title":"Efficacy and Safety of CH-1504, a Metabolically Stable Antifolate, in Patients with Active Rheumatoid Arthritis: Results of a Phase II Multicenter Randomized Study","year":2011,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"","keywords":"Medicine; Antifolate; Rheumatoid arthritis; Internal medicine; Multicenter study; Randomized controlled trial; Arthritis; Methotrexate; Antimetabolite","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002938388,0.0009680428,0.002252382,0.0004091872,0.0003588343,0.0006511153,0.0008586837,0.00141665,0.003079577],"category_scores_gemma":[0.001867842,0.0005784947,0.001052066,0.0004076905,0.0009139868,0.0007480454,0.0002976427,0.001433141,0.0004844887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006590953,"about_ca_system_score_gemma":0.001092163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006229755,"about_ca_topic_score_gemma":0.001644073,"domain_scores_codex":[0.9987335,0.0008132086,0.00009822905,0.0001446633,0.0001071354,0.0001033333],"domain_scores_gemma":[0.998507,0.0004384588,0.0004303041,0.0001200182,0.0001101813,0.0003940274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9289329,0.01527843,0.0042825,0.0006071331,0.001409476,0.00008865696,0.000100617,0.0003789263,0.01467716,0.00006247,0.000682405,0.03349931],"study_design_scores_gemma":[0.7723696,0.2161049,0.00868583,0.00002257039,0.000728037,0.00008781061,0.00002490662,0.0003797048,0.001034315,0.00004069549,0.0005025676,0.00001898733],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933648,0.003230502,0.0004211098,0.0002165181,0.00007989143,0.001414065,0.0005537869,0.00006827627,0.0006509716],"genre_scores_gemma":[0.9943224,0.001335137,0.001004852,0.0005940776,0.0001736715,0.001149116,0.000841581,0.0000142629,0.0005649151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003079577,"threshold_uncertainty_score":0.01553988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01548088899823744,"score_gpt":0.2829190717590095,"score_spread":0.267438182760772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}