{"id":"W2312543109","doi":"10.4161/cc.5.6.2583","title":"Revealing Hidden Relationships Among Yeast Genes Involved in Chromosome Segregation Using Systematic Synthetic Lethal and Synthetic Dosage Lethal Screens","year":2006,"lang":"en","type":"review","venue":"Cell Cycle","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Cancer Institute; Terry Fox Foundation; Michael Smith Health Research BC; Canadian Institutes of Health Research; Genome Canada; Ontario Genomics; Ontario Genomics Institute","keywords":"Biology; Genetic screen; Synthetic lethality; Gene; Genetics; Genome; Computational biology; Model organism; Kinetochore; Chromosome; Phenotype; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008655022,0.0004646638,0.001005311,0.0002689455,0.0001943185,0.0001073575,0.0003223986,0.000640837,0.00000981244],"category_scores_gemma":[0.0001675115,0.0004247176,0.0002489536,0.0003061155,0.0001898668,0.00001054621,0.0002664345,0.0004939266,0.00002599628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001024876,"about_ca_system_score_gemma":0.0001877291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001784185,"about_ca_topic_score_gemma":0.0001472548,"domain_scores_codex":[0.9967012,0.0009160011,0.0008107839,0.0007643414,0.0003259589,0.0004817597],"domain_scores_gemma":[0.99866,0.0001230184,0.0003614318,0.0006280841,0.00007693029,0.0001504964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.00007592013,0.0007795083,0.003411786,0.7778631,0.0006421037,0.0005142858,0.0004531439,0.002833328,0.1449898,0.0001367458,0.0001794606,0.06812081],"study_design_scores_gemma":[0.007736471,0.001709829,0.002477952,0.7505261,0.01118883,0.003020626,0.002668888,0.04756961,0.08655814,0.00125358,0.06774417,0.01754579],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1716154,0.826534,0.0001043619,0.000004875126,0.00008955972,0.001135781,0.00006147951,0.00001482908,0.0004397602],"genre_scores_gemma":[0.4078,0.5896397,0.0007527329,0.000004022279,0.0002998772,0.000160124,0.0004511614,0.0001502183,0.0007421807],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.2368943,"threshold_uncertainty_score":0.9998205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05538780240691177,"score_gpt":0.2952790579526492,"score_spread":0.2398912555457374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}