{"id":"W2312578576","doi":"10.1021/bm800412r","title":"DNA Interaction with Antitumor Polyamine Analogues: A Comparison with Biogenic Polyamines","year":2008,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada","keywords":"Polyamine; Spermidine; Spermine; Putrescine; DNA; Guanine; Chemistry; Stereochemistry; Biochemistry; Macromolecule; Enzyme; Nucleotide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001428735,0.0002892163,0.0002884821,0.0001146233,0.0001129203,0.0001807046,0.0002037401,0.0004556311,0.0007810966],"category_scores_gemma":[0.0003020865,0.0001171664,0.0002076218,0.0001308921,0.0001559599,0.0002328437,0.0001223426,0.0002816651,0.0002014808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001622486,"about_ca_system_score_gemma":0.00008101668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004485035,"about_ca_topic_score_gemma":0.0007541724,"domain_scores_codex":[0.9997855,0.00006036574,0.0000113431,0.00004962151,0.00006020188,0.00003299181],"domain_scores_gemma":[0.9997681,0.00009482635,0.00004691479,0.00001289553,0.00004730714,0.0000299205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008708083,0.00001467275,0.0002046711,0.00009993153,0.00001082298,0.0000222668,0.00002049411,0.0001203082,0.9980146,0.00002073256,0.00001066766,0.001373732],"study_design_scores_gemma":[0.000007844587,0.0008185246,0.003046505,0.000009751757,0.00002096631,0.0001784957,0.00003255838,0.0007028684,0.9931902,0.00001171903,0.001974273,0.000006295445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990841,0.006198144,0.001655642,0.00003998787,0.00001900026,0.00001714504,0.00006341151,0.00001396217,0.001151612],"genre_scores_gemma":[0.9931366,0.002396057,0.002292778,0.00006895886,0.00001128474,0.00002495308,0.0002564364,0.000008265814,0.00180463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007810966,"threshold_uncertainty_score":0.002613008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01597244428841007,"score_gpt":0.2550124998581409,"score_spread":0.2390400555697308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}