{"id":"W2312578576","doi":"10.1021/bm800412r","title":"DNA Interaction with Antitumor Polyamine Analogues: A Comparison with Biogenic Polyamines","year":2008,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada","keywords":"Polyamine; Spermidine; Spermine; Putrescine; DNA; Guanine; Chemistry; Stereochemistry; Biochemistry; Macromolecule; Enzyme; Nucleotide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004448514,0.00027995,0.0002484813,0.0001195192,0.0002052376,0.00002947836,0.0002355845,0.00008774544,0.00001255365],"category_scores_gemma":[0.00001463167,0.0002074475,0.0000747737,0.0003457966,0.0003072707,0.00001119265,0.00006859504,0.000068047,0.00003315623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001035837,"about_ca_system_score_gemma":0.00008643839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001385835,"about_ca_topic_score_gemma":0.0002328102,"domain_scores_codex":[0.9987205,0.00003958921,0.0002422672,0.0004861886,0.0001820421,0.0003294605],"domain_scores_gemma":[0.9991247,0.000009264068,0.0001531691,0.00048586,0.00009813387,0.0001288737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002272321,0.0002464691,0.009849788,0.0000114172,0.0001167581,0.00004969496,0.00005671126,0.000005568522,0.9873317,0.0001111926,0.001153371,0.0008400547],"study_design_scores_gemma":[0.001050077,0.0007065047,0.02957513,0.0000248468,0.00006949626,0.001189563,0.0001547698,0.00003932432,0.9370121,0.000005720286,0.02973811,0.0004343608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915508,0.001397812,0.005761387,0.000162292,0.00005804738,0.0002403271,0.0000885753,0.00005489574,0.0006858567],"genre_scores_gemma":[0.995629,0.0001585584,0.002640391,0.0001478705,0.0002222274,0.00006368619,0.0006529207,0.00004329733,0.0004420528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05031965,"threshold_uncertainty_score":0.8459466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01597244428841007,"score_gpt":0.2550124998581409,"score_spread":0.2390400555697308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}