{"id":"W2312705855","doi":"10.1038/ncomms11171","title":"GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Vlaamse regering; Universiteit Gent; University of Toronto; European Hematology Association; Fonds Wetenschappelijk Onderzoek; California Institute of Technology; University of Pennsylvania","keywords":"Cell fate determination; Cell biology; Biology; Notch signaling pathway; Cellular differentiation; Cell; Reprogramming; Transcription factor; Lineage (genetic); T cell; Psychological repression; Signal transduction; Genetics; Gene; Gene expression; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009481538,0.0001599374,0.0001226534,0.0001172643,0.0000882764,0.000194896,0.0001002343,0.000115426,0.001236178],"category_scores_gemma":[0.0001084243,0.00009452109,0.0001391215,0.0000880306,0.0001696359,0.00005692495,0.0001586789,0.0002472791,0.0003049478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002469565,"about_ca_system_score_gemma":0.000269639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001463918,"about_ca_topic_score_gemma":0.002497684,"domain_scores_codex":[0.9998994,0.00001615854,0.000008636755,0.00001806936,0.00002300544,0.00003484256],"domain_scores_gemma":[0.9999381,0.0000146893,0.00001193327,0.00001273214,0.000006870896,0.000015604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001108338,0.00000840578,0.0001992183,0.00001069227,0.000001564404,0.00002970863,0.00001086649,0.0000468877,0.9986603,0.00007130863,0.00003162172,0.0008185545],"study_design_scores_gemma":[0.0000179582,0.0001220132,0.003207571,0.000003143281,0.000007249829,0.0001877817,0.00001329286,0.0006104546,0.9938327,0.0000580936,0.001937133,0.000002546112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950943,0.0007069041,0.001434159,0.00005453196,0.0000195296,0.00001684241,0.0003108621,0.0001014631,0.002261513],"genre_scores_gemma":[0.9968582,0.0002423485,0.001027664,0.00003771049,0.00000499564,0.000009607104,0.0003386104,0.0000261257,0.001454822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001463918,"threshold_uncertainty_score":0.00413543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02929821217622565,"score_gpt":0.3013045424547021,"score_spread":0.2720063302784764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}