{"id":"W2312705855","doi":"10.1038/ncomms11171","title":"GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Vlaamse regering; Universiteit Gent; University of Toronto; European Hematology Association; Fonds Wetenschappelijk Onderzoek; California Institute of Technology; University of Pennsylvania","keywords":"Cell fate determination; Cell biology; Biology; Notch signaling pathway; Cellular differentiation; Cell; Reprogramming; Transcription factor; Lineage (genetic); T cell; Psychological repression; Signal transduction; Genetics; Gene; Gene expression; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002711657,0.0001619216,0.0001727807,0.00008541778,0.000853247,0.00004135439,0.0004811765,0.0004357506,0.0001921357],"category_scores_gemma":[0.00006899923,0.0001252934,0.00005432831,0.00009017769,0.0002730719,0.000264967,0.0003221628,0.001073937,0.0001096303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006484879,"about_ca_system_score_gemma":0.00002487647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009619086,"about_ca_topic_score_gemma":0.00005198485,"domain_scores_codex":[0.9988344,0.0004239757,0.0002266728,0.0002654201,0.00003691056,0.0002125785],"domain_scores_gemma":[0.9980811,0.0003905065,0.0002082881,0.001213164,0.00008216505,0.0000248019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002886564,0.0002137832,0.0004118712,0.00000590084,0.00003043166,1.875624e-7,0.0002525232,7.391115e-8,0.9618495,0.0003020651,0.0323964,0.004508372],"study_design_scores_gemma":[0.001041086,0.00008176466,0.003038275,0.00006864119,0.00003388853,0.00001184007,0.0002735725,0.000002535416,0.6913869,0.00004339377,0.3038345,0.0001835748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9449506,0.01539013,0.0001638636,0.004589201,0.001019455,0.0002902828,0.000031715,0.0001631115,0.03340161],"genre_scores_gemma":[0.9869742,0.001122237,0.0001786572,0.0002890071,0.00001536882,0.00002957498,0.0001591122,0.00001747821,0.01121436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2714381,"threshold_uncertainty_score":0.6562572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02929821217622565,"score_gpt":0.3013045424547021,"score_spread":0.2720063302784764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}