{"id":"W2312737546","doi":"10.1021/jp308674g","title":"Binding Kinetics and Affinities of Heterodimeric versus Homodimeric HIV-1 Reverse Transcriptase on DNA–DNA Substrates at the Single-Molecule Level","year":2013,"lang":"en","type":"article","venue":"The Journal of Physical Chemistry B","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"DNA; Chemistry; Dimer; Affinities; Reverse transcriptase; Dissociation constant; Recombinant DNA; DNA replication; Nucleotide; Stereochemistry; Primer (cosmetics); Binding site; Biochemistry; Biophysics; RNA; Biology; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007043647,0.0004546233,0.0005893874,0.0003579101,0.0002677849,0.0006164761,0.0005320216,0.0006010621,0.002625134],"category_scores_gemma":[0.001623309,0.0003888595,0.0002656993,0.0003505298,0.000241913,0.0006153857,0.0002351719,0.0008086752,0.001492784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005082924,"about_ca_system_score_gemma":0.0001715285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001229666,"about_ca_topic_score_gemma":0.000908946,"domain_scores_codex":[0.9991223,0.0001710662,0.0000405529,0.0003029529,0.0002420184,0.0001210917],"domain_scores_gemma":[0.9989479,0.0006273544,0.0001154216,0.00008937821,0.0001282024,0.00009176848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002193217,0.00007526935,0.001254327,0.0000866392,0.0000238374,0.00004322896,0.0001539953,0.0007210218,0.9916767,0.0002732993,0.00009314055,0.005379194],"study_design_scores_gemma":[0.00001644481,0.0002824769,0.01077277,0.00001383585,0.000021212,0.0002054304,0.000185294,0.02058865,0.965825,0.0001828464,0.001864624,0.00004144551],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869748,0.002114197,0.008738476,0.00005908036,0.00002053481,0.00002621595,0.0001889922,0.00009612845,0.001781602],"genre_scores_gemma":[0.9885274,0.001330591,0.005866266,0.00006178652,0.0000128042,0.00006675767,0.0004407473,0.00004142656,0.003652148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002625134,"threshold_uncertainty_score":0.00878197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03885972802922043,"score_gpt":0.2514258821887898,"score_spread":0.2125661541595693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}