{"id":"W2312840436","doi":"10.1158/1538-7445.am10-2975","title":"Abstract 2975: Two putative founder MSH6 mutations associated with inherited cancer susceptibility in Ashkenazi Jewish population","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"","keywords":"MSH6; Lynch syndrome; MLH1; MSH2; Genetics; Population; Gene duplication; Colorectal cancer; Cancer; Medicine; Exon; Mutation; Biology; DNA mismatch repair; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005416127,0.0004811598,0.0003085921,0.001733035,0.0007990528,0.0004293044,0.0003952227,0.0006052966,0.00313935],"category_scores_gemma":[0.001936968,0.0002334742,0.0003098398,0.0008507922,0.0004323048,0.0001705071,0.0002898857,0.0003361097,0.0002701037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002729381,"about_ca_system_score_gemma":0.0002332775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006262633,"about_ca_topic_score_gemma":0.005061626,"domain_scores_codex":[0.9993587,0.0001435217,0.00007881728,0.0001680215,0.0001733331,0.00007759999],"domain_scores_gemma":[0.9989818,0.0002683477,0.0003408618,0.00008445684,0.0001518526,0.0001727714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003213898,0.00008244297,0.985332,0.00002026164,0.00006536632,0.00471261,0.0002869861,0.0000398783,0.005619383,0.00008169263,0.0001924977,0.003245529],"study_design_scores_gemma":[0.0000527547,0.0003282085,0.9808319,0.00001753688,0.0001260857,0.01582201,0.0002959724,0.0005077339,0.001196586,0.0001080777,0.0007006778,0.00001247016],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993472,0.0001350842,0.0001714953,0.00002922871,0.00000573185,0.000006941441,0.00006588086,0.000006549275,0.0002319588],"genre_scores_gemma":[0.9995783,0.00003847323,0.0001410212,0.00002285683,0.0000143706,0.000003067063,0.00008236982,0.000001773658,0.0001177489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006262633,"threshold_uncertainty_score":0.01245236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1022598359425544,"score_gpt":0.456214629453218,"score_spread":0.3539547935106636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}